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SKF 89976A hydrochloride Chemical Structure
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Biological Activity
SKF 89976A is a GABA transporter type 1 inhibitor with IC50 of 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. It is selective for GAT-1. It inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo. [1]
References on SKF 89976A hydrochloride
- [1] Acta Physiol Scand. 152(2):173-9;1994 Oct.
Chemical Information
| Molecular Weight (WM): | 371.9 |
|---|---|
| Formula: | C22H25NO2.HCl |
| CAS No.: | 85375-15-1 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
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