Research Area
Product Type
United States ( Change Country )
RDEA119 (BAY 869766) Chemical Structure
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Biological Activity
RDEA119 is a highly potent and selective inhibitor of mitogen activated ERK kinase (MEK), a key component of the RAS/RAF/MEK/ERK pathway that is commonly defective in human tumors . Rdea119 has favorable properties, including oral dosing, excellent selectivity and low central nervous system (CNS) penetration.
In mouse xenograft studies, when rdea119 was dosed orally once daily for 14 days, there are significant inhibition and delay of tumor growth. We observed inhibition of pERK in tumors (the target of therapy) at significantly lower concentrations (EC50 = 73 nM), compared to those required to inhibit brain pERK (EC50 > 5,000 nM).
Chemical Information
| Molecular Weight (WM): | 572.34 |
|---|---|
| Formula: | C19H20F3IN2O5S |
| CAS No.: | 923032-37-5 |
| Synonyms: |
BAY 869766
|
| Dissolve in (25°C): | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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