(-)-Parthenolide

Catalog No.S2341

(-)-Parthenolide Chemical Structure

Molecular Weight(MW): 248.32

(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

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  •  G. To evaluate effects of IKBKE/TBK1 inhibition on NF-κB signaling in Ewing, TC32 cells were incubated with CYT387 for six hours prior to stimulation with TNF-α (30 ng/mL). IκBα degradation was measured by harvesting TC32 cells thirty minutes after stimulation with TNF-α. TNF-α stimulation resulted in degradation of IκBα, and this effect was attenuated with CYT387 treatment. Parthenolide, an inhibitor of IκBα phosphorylation was used as a positive control. Similar effects of CYT387 activity were seen in HEK-293T cells which also express IKBKΕ. Nuclear extracts were prepared from TC32 cells harvested following forty-five minutes of TNF-α stimulation. Treatment with CYT387 resulted in decreased nuclear localization of NF-κB family proteins RelA/p65 and c-Rel. There was a modest impairment of p50 nuclear localization as compared to parthenolide and DMSO controls and no change in p52 nuclear localization. RelB (not shown) is not expressed in TC32 cells

    Harvard University, 2014.. (-)-Parthenolide purchased from Selleck.

    PAR inhibited the production of TNF-α and IL-17 in vitro in a dose dependent manner. Lymph node MNCs harvested from EAN rats on day 8 p.i. were cultured in the presence of BPM and a series of concentrations of PAR. 72 h later, culture supernatants were collected and the levels of TNF-α and IL-17 were detected by ELISA. The results are expressed as mean ± SD (*p < 0.05, **p < 0.01). Data represented three experiments.

    J Neuroimmunol, 2017, 305:154-161. (-)-Parthenolide purchased from Selleck.

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Biological Activity

Description (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
Targets
HDAC1 [1] NF-κB [2] MDM2 ubiquitination [3] p53 [3]
()

Protocol

Solubility (25°C)

In vitro DMSO 49 mg/mL (197.32 mM)
Ethanol 49 mg/mL warmed (197.32 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+corn oil
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 248.32
Formula

C15H20O3

CAS No. 20554-84-1
Storage powder
Synonyms N/A

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HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID