Catalog No.S1478 Synonyms: MCH 32
Molecular Weight(MW): 791.06
Oligomycin A is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.
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(F) Detection of expression of SDHA and TOMM20 by immunoblotting in wild-type and Atg7-/- K562 cells with indicated drugs. The expression levels were quantified with number indicated. (G) Quantification analysis of mitochondrial mass in wild-type and Atg7-/- K562 cells when cultured with oligomycin(100 ng/ml), antimycin A(50 μM) and Baf-A1(10 nM).
Sci Rep, 2016, 6:24641.. Oligomycin A purchased from Selleck.
(A) Replication of the H6N2 and H7N1 AIV was measured in presence or absence of 125μμM oligomycin. CLEC213 cells were infected at an MOI of 1. Total RNA was extracted 16 h pi and segment 7 vRNA was quantified by qRT-PCR. Results are expressed as copy numbers per μμg of total RNA, *: p-value<0.05, ***: p-value<0.001. (B) Minigenome activity in H6N2-infected cells in the presence or absence of oligomycin (125μμM). Results are expressed as a ratio of RLU on β-Gal activity ± SEM, ***: p-value<0.001.
PLoS One, 2017, 12(4):e0176355. Oligomycin A purchased from Selleck.
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|Description||Oligomycin A is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.|
Oligomycin A is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.Oligomycin A inhibits ATP synthase by blocking its proton channel (Fo subunit), which is necessary for oxidative phosphorylation of ADP to ATP. The inhibition of ATP synthesis by oligomycin A will significantly reduce electron flow through the electron transport chain; however, electron flow is not stopped completely due to a process known as proton leak or mitochondrial uncoupling.  In a group of cancer cells, Oligomycin at 100 ng/ml completely inhibits oxidative phosphorylation activity in 1 h and induces various levels of glycolysis gains by 6 h.  Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis.  Oligomycin inhibits mitochondrial respiration in melanoma, sensitizes melanoma cells to therapy, blocks the emergence of the slow-cycling, long-term tumor-maintaining melanoma cells. 
|In vitro||DMSO||10 mg/mL (12.64 mM)|
|In vivo||Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
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