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LX 1606 hippurate Chemical Structure
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Biological Activity
LX 1606 hippurate is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Upon administration, LX 1606 hippurate is converted to its active metabolite LP-778902, which binds to and blocks the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells. [1]
References on LX 1606 hippurate
- [1] http://www.cancer.gov/drugdictionary/?CdrID=662188 ;
Chemical Information
| Molecular Weight (WM): | 754.15 |
|---|---|
| Formula: | C27H26ClF3N6O3.C9H9NO3 |
| CAS No.: | 1137608-69-5 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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