Dehydroepiandrosterone (DHEA)

Catalog No.S2604

Dehydroepiandrosterone (DHEA) Chemical Structure

Molecular Weight(MW): 288.43

Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.

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Biological Activity

Description Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.
Targets
Androgen Receptor [1]
In vitro

Dehydroepiandrosterone reversibly blocks GABA-induced currents, behaving as an allosteric antagonist of the GABAA receptor in cultured neurons from ventral mesencephalon. [1] Dehydroepiandrosterone (DHEA) protects primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity, DHEAS also reduces NMDA-induced toxicity. DHEA (100 nM) protects cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well. [2] Dehydroepiandrosterone (DHEA) increases the length of neurites containing the axonal marker Tau-1 in primary cultures of mouse embryonic neocortical neurons, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion. Dehydroepiandrosterone (DHEA) rapidly increases free intracellular calcium via activation of N-methyl-D-aspartate (NMDA) receptors. [3] Dehydroepiandrosterone with H874Y stimulates a 3- to 8-fold greater response than with wild type AR and at 100 nM the response is similar with the LNCaP mutant in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells. [4]

In vivo Dehydroepiandrosterone increases the number of newly formed cells in the dentate gyrus of the hippocampus of adult male rats, and also antagonizes the suppressive of corticosterone (40 mg/kg body weight daily for 5 days). Dehydroepiandrosterone by itself increases the number of newly formed neurons, but only if treatment is continued throughout the period of survival. [5]

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (197.62 mM)
Ethanol 57 mg/mL (197.62 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 288.43
Formula

C19H28O2

CAS No. 53-43-0
Storage powder
Synonyms N/A

Bio Calculators

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02683148 Recruiting Synovial Sarcoma|Sarcoma, Synovial Washington University School of Medicine September 2016 Phase 1|Phase 2
NCT02736591 Recruiting Subfertility Cairo University June 2016 Phase 3
NCT02766764 Recruiting Subfertility Cairo University June 2016 Phase 4
NCT02794948 Recruiting Primary Ovarian Insufficiency Guangzhou University of Traditional Chinese Medicine April 2016 Early Phase 1
NCT02561793 Recruiting Subfertility Cairo University October 2015 Phase 3
NCT02549690 Not yet recruiting Infertility Vietnam National University|Mỹ Đức Hospital September 2015 --

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Androgen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID