Molecular Weight(MW): 288.43
Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.
Purity & Quality Control
Choose Selective Androgen Receptor Inhibitors
|Description||Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.|
Dehydroepiandrosterone reversibly blocks GABA-induced currents, behaving as an allosteric antagonist of the GABAA receptor in cultured neurons from ventral mesencephalon.  Dehydroepiandrosterone (DHEA) protects primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity, DHEAS also reduces NMDA-induced toxicity. DHEA (100 nM) protects cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well.  Dehydroepiandrosterone (DHEA) increases the length of neurites containing the axonal marker Tau-1 in primary cultures of mouse embryonic neocortical neurons, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion. Dehydroepiandrosterone (DHEA) rapidly increases free intracellular calcium via activation of N-methyl-D-aspartate (NMDA) receptors.  Dehydroepiandrosterone with H874Y stimulates a 3- to 8-fold greater response than with wild type AR and at 100 nM the response is similar with the LNCaP mutant in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells. 
|In vivo||Dehydroepiandrosterone increases the number of newly formed cells in the dentate gyrus of the hippocampus of adult male rats, and also antagonizes the suppressive of corticosterone (40 mg/kg body weight daily for 5 days). Dehydroepiandrosterone by itself increases the number of newly formed neurons, but only if treatment is continued throughout the period of survival. |
|In vitro||DMSO||57 mg/mL (197.62 mM)|
|Ethanol||57 mg/mL (197.62 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02683148||Recruiting||Synovial Sarcoma|Sarcoma, Synovial||Washington University School of Medicine||September 2016||Phase 1|Phase 2|
|NCT02736591||Recruiting||Subfertility||Cairo University||June 2016||Phase 3|
|NCT02766764||Recruiting||Subfertility||Cairo University||June 2016||Phase 4|
|NCT02794948||Recruiting||Primary Ovarian Insufficiency||Guangzhou University of Traditional Chinese Medicine||April 2016||Early Phase 1|
|NCT02561793||Recruiting||Subfertility||Cairo University||October 2015||Phase 3|
|NCT02549690||Not yet recruiting||Infertility||Vietnam National University|Mỹ Đức Hospital||September 2015||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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