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Cytochrome P450 14a-demethylase inhibitor 1n Chemical Structure
Voriconazole
Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections.
Cytochrome P450 14a-demethylase inhibitor 1a
Cytochrome P450 14a-demethylase inhibitor 1a is an antifungal agent and an analog of fluconazole with an MIC80 of 3.9 ng/ml against Candida albicans.
Cytochrome P450 14a-demethylase inhibitor 1b
Cytochrome P450 14a-demethylase inhibitor 1b is an antifungal agent and an analog of fluconazole with an MIC80 of 3.9 ng/ml against Candida albicans and Microsporum gypseum.
Cytochrome P450 14a-demethylase inhibitor 1c
Cytochrome P450 14a-demethylase inhibitor 1c is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Candida albicans and Microsporum gypseum.
Cytochrome P450 14a-demethylase inhibitor 1d
Cytochrome P450 14a-demethylase inhibitor 1d is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Candida albicans and Microsporum gypseum.
Cytochrome P450 14a-demethylase inhibitor 1e
Cytochrome P450 14a-demethylase inhibitor 1e is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Candida albicans.
Cytochrome P450 14a-demethylase inhibitor 1f
Cytochrome P450 14a-demethylase inhibitor 1f is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Candida albicans.
Cytochrome P450 14a-demethylase inhibitor 1g
Cytochrome P450 14a-demethylase inhibitor 1g is an antifungal agent and an analog of fluconazole with an MIC80 of 0.25 µg/ml against Candida albicans.
Cytochrome P450 14a-demethylase inhibitor 1h
Cytochrome P450 14a-demethylase inhibitor 1h is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Microsporum gypseum.
Cytochrome P450 14a-demethylase inhibitor 1i
Cytochrome P450 14a-demethylase inhibitor 1i is an antifungal agent and an analog of fluconazole with an MIC80 of 62.5 ng/ml against Candida albicans.
Biological Activity
Cytochrome P450 14a-demethylase inhibitor 1n is an antifungal agent and an analog of fluconazole with an MIC80 of 0.25 µg/ml against Candida parapsilosis. It exhibits higher activity against nearly all fungi tested except Aspergillus fumigates than fluconazole. It shows higher activity than that of the other positive controls. Its MIC80 against Candida tropicalis and Candida Krusei and is 0.25 µg/ml. Its MIC80 against Candida albicans, Cryptococcus neoformans, Trichophyton rubrum and Microsporum gypseum is 1 µg/ml. [1]
References on Cytochrome P450 14a-demethylase inhibitor 1n
- [1] Eur J Med Chem. 2009 May;44(5):1913-20
Product Information
| Molecular Weight (WM): | 453.31 |
|---|---|
| Formula: | C21H20Cl2F2N4O |
| CAS No.: | 1155361-12-8 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
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