Research Area
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Cerubidine (Daunorubicin HCl, Rubidomycin HCl) Chemical Structure
Irinotecan
Irinotecan is a topoisomerase I inhibitor with an IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively.
Adriamycin (Doxorubicin)
Adriamycin (Doxorubicin) is a topoisomerase II inhibitor with IC50 of 1 and 2 μM for the inhibition of MCF-7 and MDA-MB231.
Epirubicin Hydrochloride
Epirubicin Hydrochloride (Ellence) is an anthracyclin antibiotics and a DNA topoisomerase II inhibitor with an IC50 of 12 μg/ml on an estrogen-receptor- positive ER (+) hyperdiploid EAT cell line.
Etoposide (VP-16)
Etoposide (VP-16) is a Topoisomerase II inhibitor (IC50 = 59.2 μM).
Idarubicin HCl
Idarubicin is the anthracycline antibiotic and target DNA topoisomerase II (topo II). MCF-7 cells were sensitive to idarubicin, with an IC 50 value for growth inhibition of 0.01 μM
Topotecan HCl
Topotecan Hydrochloride is a topoisomerase I inhibitor with an IC50 of 13 and 2 nM for MCF-7 Luc cells and DU-145 Luc cells.
Camptothecin
Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I) with an IC50 and IC70 of 50 nM and 0. 225 μM .
Amonafide
Amonafide is a drug used in the treatment of cancer.
Moxifloxacin hydrochloride
Moxifloxacin(Avelox, Avalox) is a fourth generation synthetic fluoroquinolone antibacterial agent.
Irinotecan HCl Trihydrate (Campto)
Irinotecan hydrochloride trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar, Campto, CPT-11) which is a topoisomerase I inhibitor with IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively.
Biological Activity
Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus (IC50=0.5μM). On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) has the highest preference for two adjacent G/C base pairs flanked on the 5’ side by an A/T base pair. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) effectively binds to every 3 base pairs and induces a local unwinding angle of 11o, but negligible distortion of helical conformation. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is most commonly used to treat specific types of leukaemia (acute myeloid leukemia and acute lymphocytic leukemia). Cerubidine (Daunorubicin HCl, Rubidomycin HCl) was initially isolated from Streptomyces peucetius. [1][2][3]
Product Information
| Molecular Weight (WM): | 563.98 |
|---|---|
| Formula: | C27H29NO10.HCl |
| CAS No.: | 23541-50-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥72mg/mL |
| Water ≥113mg/mL | |
| Ethanol ≥10mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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