New PDE Inhibitors

Catalog No.	Product Name	Information
E7369	Zaprinast	Zaprinast (M&B 22948) is an inhibitor of cGMP‑hydrolyzing phosphodiesterase isoforms and inhibits PDE5 and PDE6 with IC50 of approximately 0.50–0.76 μM and 0.15 μM, respectively. It Post‑training administration of zaprinast impairs spatial memory by increasing PDE5 expression in the rat hippocampus.
E1566	Ensifentrine	Ensifentrine (RPL-554) is a first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50 values of 0.4 nM and 1479 nM, respectively. Ensifentrine also inhibits lipopolysaccharide-induced tumor necrosis factor alpha release from human monocytes in a concentration-dependent manner. Ensifentrine demonstrates bronchoprotective and anti-inflammatory activities and can be used for chronic obstructive pulmonary disease (COPD) research.
≡ All PDE Inhibitors