HomeNew FGFR Inhibitors

New FGFR Inhibitors

Catalog No. Product Name Information
E1757 Gunagratinib Gunagratinib (ICP-192) is a pan-FGFR (fibroblast growth factor receptors) inhibitor with IC50 of 1.4, 1.5, 2.4 and 3.5 nM for FGFR1-4, respectively. It has the potential to treat advanced solid tumors.
E1814 Resigratinib Resigratinib (KIN-3248) is a potent, kinome selective, irreversible, orally bioavailable, small-molecule inhibitor of pan-FGFR. It exhibits dose-dependent tumor inhibition in FGFR driven cholangiocarcinoma, gastric, and bladder cancer xenograft models.
E1979 Irpagratinib Irpagratinib (ABSK011) is a potent inhibitor of FGFR4 with an IC50 of < 10 nM in biochemical assays. It effectively suppresses FGFR4 auto-phosphorylation and disrupts downstream signal transduction. It also strongly inhibits tumor growth and induces regression in subcutaneous xenograft models.
F0331 FGF Receptor 1 Rabbit mAb FGF Receptor 1,FGFR1
S8547 Rogaratinib Rogaratinib(BAY-1163877) is a highly potent and selective small molecule inhibitor of pan‐FGFR kinase activity, which specifically inhibits FGFR1, 2, 3 and 4 with an IC50 values of 1.8 nM, <1 nM, 9.2 nM and 1.2 nM respectively. It demonstrates robust efficacy in cancers with altered FGFR mRNA expression.
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