| A2411 |
Polzastobart (Anti-LILRB2 / ILT4 / CD85d) |
Polzastobart (Anti-LILRB2 / ILT4 / CD85d) is a humanized monoclonal antibody directed against the inhibitory immune checkpoint receptor leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2; immunoglobulin-like transcript 4; ILT4; lymphocyte immunoglobulin-like receptor 2; LIR2; monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD85d), with potential immunomodulating and antineoplastic activities. |
Human IgG4SP |
| A2047 |
Alirocumab (anti-PCSK9) |
Alirocumab (anti-PCSK9) works by inhibiting the PCSK9 protein, which binds to the low-density lipoprotein receptor (LDLR) and causes receptor degradation, removing less LDL cholesterol from the circulation. |
human IGg1, κ |
| A2412 |
Falbikitug (Anti-LIF) |
Falbikitug (Anti-LIF) is a humanized immunoglobulin G1 (IgG1) monoclonal antibody against leukemia inhibitory factor (LIF), with potential immunomodulating and antineoplastic activities. MW: 145.24 kD. |
Human IgG1 |
| A2048 |
Necitumumab (anti-EGFR) |
Necitumumab (anti-EGFR) is an epidermal growth factor receptor (EGFR) antagonist that can be used in combination with gemcitabine and cisplatin for the first-line treatment of patients with metastatic squamous non-small cell lung cancer. |
human IGg1, κ |
| A2413 |
Mibavademab (Anti-LEPR / CD295) |
Mibavademab (Anti-LEPR / CD295) is a humanized monoclonal antibody against LEPR (Leptin receptor). MW: 145.5 kD. |
Human IgG4SP |
| A2414 |
Anti-LAMP1 / CD107a |
Anti-LAMP1 / CD107 is a monoclonal antibody against lysosome-associated membrane protein 1 (LAMP1) with potential antineoplastic activity. MW: 145.5 kD. |
Human IgG1 |
| A2416 |
Anti-Klotho Beta |
Anti-Klotho Beta is an antibody targeting Beta Klotho (KLB). MW: 145.24 kD. |
Human IgG1 |
| A2417 |
Anti-KLK2 / Kallikrein 2 |
Anti-KLK2 / Kallikrein 2 contains h11B6, a humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets human kallikrein-2 (hK2), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), with potential antineoplastic activity. MW: 145.5 kD. |
Human IgG1 |
| A2418 |
Lacutamab (Anti-KIR3DL2 / CD158k) |
Lacutamab (Anti-KIR3DL2 / CD158k) is a humanized monoclonal antibody against the immune receptor human killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 (KIR3DL2), with potential immunomodulating and antineoplastic activities. MW: 150 kD. |
Human IgG1 |
| A2049 |
Evinacumab(anti-ANGPTL3) |
Evinacumab is a monoclonal antibody that targets, binds to, and pharmacologically inhibits ANGPTL3, which can act as a complementary agent to other LDL-C lowering regimens for patients aged 12 or older with HoFH. |
human IGg1, λ |
| A2419 |
Lirilumab (Anti-KIR) |
Lirilumab (Anti-KIR) is a fully human monoclonal antibody against killer-cell immunoglobulin-like receptors (KIR), with potential antineoplastic activity. Lirilumab can be used in Leukemia, squamous cell carcinoma of the head and neck (SCCHN) research. MW: 150 kD. |
Human IgG4SP |
| A2420 |
Anti-Integrin b1 / ITGB1 / CD29 |
Anti-Integrin b1 / ITGB1 / CD29 is a humanized monoclonal antibody directed against the human integrin receptor beta-1 subunit (CD29), with potential antineoplastic activity. MW: 145.5 kD. |
Human IgG1 |
| A2050 |
Romosozumab(anti-sclerostin) |
Romosozumab is a monoclonal antibody that binds to sclerostin (an inhibitor of the Wingless-related integration site (Wnt) signaling pathway). It is a new osteoanabolic drug, that simultaneously increases bone formation and decreases bone resorption. |
human IGg2, κ |
| A2421 |
Efalizumab (Anti-Integrin aL / ITGAL / CD11a) |
Efalizumab (Anti-Integrin aL / ITGAL / CD11a) is a humanized IgG1 monoclonal antibody directed against CD11a, the alpha subunit of human leukocyte-function-associated antigen type 1 (LFA-1), with immunosuppressant activity. MW: 145.5 kD. |
Human IgG1 |
| A2422 |
Garetosmab (Anti-INHBA / Activin A) |
Garetosmab (Anti-INHBA / Activin A) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research. MW: 145.5 kD. |
Human IgG4SP |
| A2423 |
Enokizumab (Anti-IL-9) |
Enokizumab (Anti-IL-9) is a humanized monoclonal antibody directed against the cytokine interleukin-9 (IL-9), with potential immunomodulating activity. MW: 145.5 kD. |
Human IgG1 |
| A2424 |
Anti-IL-7Ra / CD127 |
Anti-IL-7Ra / CD127 is a monoclonal antibody against human IL-7Rα with therapeutic benefit against T-ALL (T-cell acute lymphoblastic leukemia). MW: 145.5 kD. |
Human IgG1 |
| A2427 |
Benralizumab (Anti-IL-5Ra/ CD125) |
Benralizumab (Anti-IL-5Ra/ CD125) is an afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra) with potential anti-asthmatic activity. MW: 145.5 kD. |
Human IgG1 |
| A2428 |
Mepolizumab (Anti-IL-5) |
Mepolizumab (Anti-IL-5) is a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against interleukin-5 (IL-5) with anti-asthmatic and potential immunosuppressive activity. MW: 145.5 kD. |
Human IgG1 |
| A2431 |
Talacotuzumab (Anti-IL-3Ra / CD123) |
Talacotuzumab (Anti-IL-3Ra / CD123) is a humanized IgG1 monoclonal antibody against CD123 (Interleukin-3 receptor alpha chain or IL3RA) with potential antineoplastic activity. MW: 146.06 kD. |
Human IgG1 |