SphK Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7177 PF-543

PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform.

Selective SphK1, Ki: 3.6 nM; SphK1, IC50: 2.0 nM