Home Transmembrane Transporters OAT OAT1 Inhibitors

OAT1 Inhibitors

  • OAT1
  • OAT3
  • URAT1
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S5189 Lesinurad sodium Lesinurad (Selexipag, RDEA-594) sodium (Zurampic) is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout. Lesinurad sodium inhibits the uric acid transporter URAT1 and Kidney transporter OAT with IC50/Km of 4.3 μM/0.85 μM and 3.5 μM/2 μM for OAT1 and OAT3, respectively. Pan OAT1, IC50: 4.3 μM; OAT1, Km: 0.85 μM