Home GPCR & G Protein -Immunology & Inflammation CCR CCR2 Selective Inhibitors | Antagonists

CCR2 Selective Inhibitors | Antagonists

  • CCR1
  • CCR2
  • CCR3
  • CCR4
  • CCR5
  • CCR8
  • CCL
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S8220 INCB3344 INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. Selective hCCR2, IC50: 5.1 nM
S8361 PF-4136309 PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2. Selective CCR2, IC50: 5.2 nM
S9738 RS504393 RS504393, an extremely selective CC chemokine receptor (CCR) 2 antagonist with IC50 of 98 nM, also targets multiple receptors for inhibition of CCR2b and CCR1 receptors when administrated in higher concentration. Selective CCR2, IC50: 98 nM
S7538 RS-102895 Hydrochloride RS-102895 hydrochloride (HCl) is a potent antagonist of Chemokine (C-C motif) receptor 2 (CCR2) with IC50 of 360 nM, and shows no effect on CCR1. RS-102895 hydrochloride also inhibits human α1a and α1d receptors, rat brain cortex 5-HT1a receptor in cells with IC50s of 130 nM, 320 nM, 470 nM, respectively. Selective CCR2, IC50: 360 nM
S3383 RS102895 RS 102895 is a small molecule antagonist of CCR2 with an IC50 of 360 nM. Selective CCR2, IC50: 360 nM
S8512 Cenicriviroc Cenicriviroc is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity. Pan
S0085 BMS-813160 BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion. Pan