5-HT7 Selective Inhibitors | Antagonists
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.
|Selective||5-HT7, pKi: 8.3|
Asenapine is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
|Pan||5-HT7, pKi: 9.94|
Risperidone is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder.
|Pan||5-HT7, Ki: 6.6 nM|
|S8021||Vortioxetine (Lu AA21004) HBr||
Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
|Pan||5-HT7, Ki: 19 nM|
BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
|Pan||5-HT7, pKi: 6.3|
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