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SMARCA2 Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E0111 BRM/BRG1 ATP Inhibitor-1 (BRM014) BRM/BRG1 ATP Inhibitor-1 (Compound 14) is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 (BRG1) with IC50s below 0.005 µM.
Chem Sci, 2023, 14(8):2168-2182
E1178 FHD-286 (Camibirstat) Camibirstat (FHD-286) is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia.
E0449 SGC-SMARCA-BRDVIII

SGC-SMARCA-BRDVIII is a potent and selective SMARCA2/4 BRD inhibitor.
E1711 FHT-1015 FHT-1015 is a potent, small-molecule, allosteric inhibitor of SMARCA4/SMARCA2 ATPase with IC50 values ≤10 nM. FHT-1205 decreases PD1+TIM3+ cells and cytokine expression in vivo.