CAS No. 10122-45-9
Batch:
Purity:99.88
Chemical Structure
Check the
ZZW-115
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N,N-dimethyl-2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanamine;trihydrochloride | |
|---|---|---|
| CAS Number | 10122-45-9 | |
| Molecular Formula |
C₂₄H₃₄Cl₃F₃N₄S |
|
| Molecular Weight (MW) | 573.97 | |
| SMILES | Cl.Cl.Cl.CN(C)CCN1CCN(CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CC1 | |
| InChIKey | OBSKIDNFCBBXKJ-UHFFFAOYSA-N |
ZZW-115 is a potent nuclear protein 1 (NUPR1) inhibitor. By binding to NUPR1, ZZW-115 competes with importins to prevent NUPR1 nuclear translocation, thereby disrupting downstream stress response networks. This inhibition causes mitochondrial dysfunction, ATP depletion, and reactive oxygen species accumulation, culminating in cell death via necroptosis and apoptosis as well as robust antitumor activity in vivo. [1][2]
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Concentration
Volume
Mass
|
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(162.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 46 mg/mL |
| Ethanol | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.