CAS No. 2922732-54-3,3034802-05-3

Batch: Purity:99.68
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Zoldonrasib (RMC-9805) Chemical Structure
Chemical Structure
Check the Zoldonrasib (RMC-9805) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-cyclopentyl-2-[(5S)-2-[(2R,3R)-3-cyclopropyl-1-methylaziridine-2-carbonyl]-2,7-diazaspiro[4.4]nonan-7-yl]-N-[(6S,8S,14S)-21-[5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]-3-pyridinyl]-18,18-dimethyl-9,15-dioxo-22-(2,2,2-trifluoroethyl)-5,16-dioxa-2,10,22,28-tetrazapentacyclo[18.5.2.12,6.110,14.023,27]nonacosa-1(26),20,23(27),24-tetraen-8-yl]acetamide
CAS Number 2922732-54-3,3034802-05-3
Molecular Formula

C63H88F3N11O7
Molecular Weight (MW) 1168.44
InChIKey VKNNQJWNUPSOEK-VCAAAJMFSA-N

Ordering Information

Biological Activity

Zoldonrasib (RMC-9805) is an orally active, mutant-selective covalent tri-complex inhibitor targeting active KRAS G12D. By binding cyclophilin A to form a neomorphic protein-protein complex with GTP-bound KRAS G12D, it selectively modifies the mutant aspartic acid residue to suppress downstream RAS signaling. This pathway inhibition blocks cell proliferation, induces apoptosis, and drives tumor regression in preclinical KRAS G12D-driven cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (85.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.