CAS No. 2951015-31-7
Chemical Structure
Check the
YDR1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[4-[[1-[4-[[4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]-2-fluorophenyl]piperidin-4-yl]methyl]piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione | |
|---|---|---|
| CAS Number | 2951015-31-7 | |
| Molecular Formula | ||
| InChIKey | NKECFXWADFBMPA-UHFFFAOYSA-N |
YDR1 is a selective, orally bioavailable Cereblon-based proteolysis targeting chimera that acts as a potent degrader of SMARCA2. By targeting SMARCA2 for proteasomal degradation, this compound disrupts SWI/SNF chromatin remodeling complex activity, downstream gene expression, and oncogenic signaling pathways. Consequently, SMARCA2 degradation exhibits robust antitumor activity and induces synthetic lethality in SMARCA4-mutant non-small cell lung cancer xenograft models. [1][2]
Note: Technical data last updated: Sep 1, 2026.