CAS No. 173897-44-4
Batch:
Purity:99.44
Chemical Structure
Check the
Y-39983 Dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide;dihydrochloride | |
|---|---|---|
| CAS Number | 173897-44-4 | |
| Molecular Formula |
C16H16N4O.2HCl |
|
| Molecular Weight (MW) | 353.25 | |
| SMILES | CC(C1=CC=C(C=C1)C(=O)NC2=C3C=CNC3=NC=C2)N.Cl.Cl | |
| InChIKey | CKFHAVRPVZNMGT-YQFADDPSSA-N |
Biological Activity
Y-39983 Dihydrochloride is a selective Rho-associated protein kinase (ROCK) inhibitor with an IC50 of 3.6 nM. By suppressing ROCK signalling, it regulates actin cytoskeleton organization, cell contraction, and neurite outgrowth. In ocular tissues, inhibition of the ROCK pathway by Y-39983 promotes trabecular meshwork relaxation, enhances aqueous humor outflow to lower intraocular pressure, and stimulates axon regeneration and survival of retinal ganglion cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(200.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 18 mg/mL |
| Ethanol | Insoluble |
| DMSO |
63 mg/mL
(178.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 63 mg/mL |
| Ethanol | 8 mg/mL |
| DMSO |
70 mg/mL
(198.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 70 mg/mL |
| Ethanol | 2 mg/mL |
| DMSO |
70 mg/mL
(198.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 70 mg/mL |
| Ethanol | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Y-39983 Dihydrochloride Solubility in DMSO
- Y-39983 Dihydrochloride Stock Solution
- Y-39983 Dihydrochloride Storage
- Y-39983 Dihydrochloride Stability
- Y-39983 Dihydrochloride Molecular Weight
- Y-39983 Dihydrochloride SMILES
- Y-39983 Dihydrochloride Chemical Structure (2D and 3D)
- Y-39983 Dihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.