CAS No. 284028-89-3
Batch:
Purity:99.95
Chemical Structure
Check the
XAV-939
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-(trifluoromethyl)phenyl]-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one | |
|---|---|---|
| CAS Number | 284028-89-3 | |
| Molecular Formula |
C14H11F3N2OS |
|
| Molecular Weight (MW) | 312.31 | |
| SMILES | C1CSCC2=C1N=C(NC2=O)C3=CC=C(C=C3)C(F)(F)F | |
| InChIKey | KLGQSVMIPOVQAX-UHFFFAOYSA-N |
XAV-939 is a selective Wnt/β-catenin pathway inhibitor that targets tankyrase 1 (TNKS1, and tankyrase 2 (TNKS2,. By inhibiting TNKS-mediated poly-ADP-ribosylation, XAV-939 stabilizes Axin, a key rate-limiting component of the β-catenin destruction complex. This enhancement of Axin stability promotes β-catenin degradation, ultimately suppressing Wnt pathway-dependent transcriptional activity and cell proliferation in cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(38.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
16 mg/mL
(51.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(48.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
12 mg/mL
(38.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
30 mg/mL
(96.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- XAV-939 Mechanism of Action: Tankyrase Inhibition in Cancer Cell Research
- XAV-939 Clinical Trials
- XAV-939 Working Concentration | Cell Culture | Treatment
- XAV-939 Solubility in DMSO
- XAV-939 Stock Solution
- XAV-939 Storage
- XAV-939 Stability
- XAV-939 Combination Database
- XAV-939 Molecular Weight
- XAV-939 SMILES
- XAV-939 Chemical Structure (2D and 3D)
- XAV-939 IC50 for Cell-based and Cell-free Assays
- XAV-939 MedChemExpress (HY-15147)? Try a better option.
- XAV-939 STEMCELL (72674)? Try a better option.
- XAV-939 Sigma (X3004)? Try a better option.
- XAV-939 Tocris (3748)? Try a better option.
- XAV-939 Cayman (13596)? Try a better option.
- XAV-939 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.