CAS No. 1223397-11-2

Batch: Purity:99.99
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WZB117 Chemical Structure
Chemical Structure
Check the WZB117 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [3-fluoro-2-(3-hydroxybenzoyl)oxyphenyl] 3-hydroxybenzoate
CAS Number 1223397-11-2
Molecular Formula

C20H13FO6
Molecular Weight (MW) 368.31
SMILES C1=CC(=CC(=C1)O)C(=O)OC2=C(C(=CC=C2)F)OC(=O)C3=CC(=CC=C3)O
InChIKey FRSWCCBXIHFKKY-UHFFFAOYSA-N

Biological Activity

WZB117 is a small-molecule inhibitor of glucose transporter 1 (GLUT1). By blocking GLUT1-mediated glucose transport, it downregulates glycolytic metabolism and lowers intracellular ATP levels, which triggers cell cycle arrest and apoptosis. Consequently, WZB117 inhibits cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (198.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 73 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.