CAS No. 50892-23-4
Batch:
Purity:99.85
Chemical Structure
Check the
WY-14643 (Pirinixic Acid)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanylacetic acid | |
|---|---|---|
| CAS Number | 50892-23-4 | |
| Molecular Formula |
C14H14ClN3O2S |
|
| Molecular Weight (MW) | 323.8 | |
| SMILES | CC1=C(C(=CC=C1)NC2=CC(=NC(=N2)SCC(=O)O)Cl)C | |
| InChIKey | SZRPDCCEHVWOJX-UHFFFAOYSA-N |
Biological Activity
WY-14643 (Pirinixic Acid) is a potent synthetic peroxisome proliferator and selective activator of peroxisome proliferator-activated receptor alpha (PPARα) with an EC50 of 1.5 μM. Activation of PPARα regulates genes involved in lipid metabolism, fatty acid oxidation, and peroxisomal proliferation. Furthermore, target engagement suppresses inflammatory responses and modulates cellular lipid homeostasis across various preclinical cell models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(200.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
| DMSO |
65 mg/mL
(200.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 52 mg/mL |
| Water | Insoluble |
| DMSO |
65 mg/mL
(200.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
| DMSO |
140 mg/mL
(432.36 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Jump to
- WY-14643 (Pirinixic Acid) Solubility in DMSO
- WY-14643 (Pirinixic Acid) Stock Solution
- WY-14643 (Pirinixic Acid) Storage
- WY-14643 (Pirinixic Acid) Stability
- WY-14643 (Pirinixic Acid) Molecular Weight
- WY-14643 (Pirinixic Acid) SMILES
- WY-14643 (Pirinixic Acid) Chemical Structure (2D and 3D)
- WY-14643 (Pirinixic Acid) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.