CAS No. 837422-57-8
Batch:
Purity:99.83
Chemical Structure
Check the
WH-4-023
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2,6-dimethylphenyl) N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamate | |
|---|---|---|
| CAS Number | 837422-57-8 | |
| Molecular Formula |
C32H36N6O4 |
|
| Molecular Weight (MW) | 568.67 | |
| SMILES | CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C | |
| InChIKey | NBTNHSGBRGTFJS-UHFFFAOYSA-N |
WH-4-023 is a potent inhibitor of Lck (IC50 2 nM) and Src (IC50 6 nM). It also potently inhibits SIK1 (IC50 10 nM), SIK2 (IC50 22 nM), and SIK3 (IC50 60 nM), displaying over 300-fold selectivity against p38α and KDR. By blocking SIK signaling, WH-4-023 suppresses CRTC3 phosphorylation, promoting nuclear translocation and enhancing anti-inflammatory IL-10 expression in macrophages. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(21.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(175.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.