CAS No. 629664-81-9

Batch: Purity:99.77
Check CoA
Turofexorate Isopropyl (XL335) Chemical Structure
Chemical Structure
Check the Turofexorate Isopropyl (XL335) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name propan-2-yl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-2,6-dihydroazepino[4,5-b]indole-5-carboxylate
CAS Number 629664-81-9
Molecular Formula

C25H24F2N2O3
Molecular Weight (MW) 438.47
SMILES CC(C)OC(=O)C1=CN(CC(C2=C1NC3=CC=CC=C32)(C)C)C(=O)C4=CC(=C(C=C4)F)F
InChIKey INASOKQDNHHMRE-UHFFFAOYSA-N

Ordering Information

Biological Activity

Turofexorate Isopropyl (WAY-362450) is a potent, selective, and orally active farnesoid X receptor (FXR) agonist with an EC50 of 4 nM. It selectively activates FXR signaling over other nuclear receptors. In animal models, treatment with WAY-362450 significantly reduces hepatic fibrosis and inflammatory cell infiltration, suppressing serum levels of mKC and MCP-1 as well as hepatic gene expression of MCP-1 and VCAM-1. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (75.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.