VTP50469 is a potent, selective Menin-MLL interaction inhibitor. It affects Menin-MLL signaling by displacing Menin and inhibiting MLL chromatin occupancy, effectively inhibiting proliferation and inducing apoptosis in MLL-rearranged leukemia.
VTP50469: Mechanism of Action
VTP50469 MOA：Targeting Menin/HOX-MEIS1 Pathway for Acute Myeloid Leukemia