CAS No. 2169916-18-9
Batch:
Purity:99.99
Chemical Structure
Check the
VTP50469
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-fluoro-2-[4-[7-[[4-(methanesulfonamido)cyclohexyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl]oxy-N,N-di(propan-2-yl)benzamide | |
|---|---|---|
| CAS Number | 2169916-18-9 | |
| Molecular Formula |
C32H47FN6O4S |
|
| Molecular Weight (MW) | 630.82 | |
| SMILES | CC(C)N(C(C)C)C(=O)C1=C(OC2=CN=CN=C2N3CC4(CCN(CC4)CC5CCC(CC5)N[S](C)(=O)=O)C3)C=CC(=C1)F | |
| InChIKey | ADHHOUXZPBYYSU-UHFFFAOYSA-N |
VTP50469 is an orally active, highly selective inhibitor of the Menin-MLL interaction (Ki 104 pM). By targeting menin, it disrupts the Menin-MLL complex and alters chromatin accessibility, leading to downregulation of oncogenic driver genes such as HOXA9 and MEIS1. This inhibition suppresses leukemic cell proliferation, induces cell differentiation, and demonstrates marked anti-leukemia activity in MLL-rearranged leukemias. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(158.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(158.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(158.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(158.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(158.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- VTP50469 Mechanism of Action: Menin Inhibition in Myeloid Blast Cell Research
- VTP50469 Working Concentration | Cell Culture | Treatment
- VTP50469 Solubility in DMSO
- VTP50469 Stock Solution
- VTP50469 Storage
- VTP50469 Stability
- VTP50469 Combination Database
- VTP50469 Molecular Weight
- VTP50469 SMILES
- VTP50469 Chemical Structure (2D and 3D)
- VTP50469 IC50 for Cell-based and Cell-free Assays
- VTP50469 Sigma (AMBH9A260597)? Try a better option.
- VTP50469 MedChemExpress (HY-114162)? Try a better option.
- VTP50469 Cayman (40759)? Try a better option.
- VTP50469 APExBIO (A8965)? Try a better option.
- VTP50469 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.