VS-4718 (PND-1186) is a potent, selective, and reversible ATP-competitive FAK inhibitor. It affects FAK/Src and PI3K/Akt signaling, by binding to the kinase domain and blocking FAK autophosphorylation at Tyr397, inhibiting tumor cell proliferation, migration, and invasion.
VS-4718 (PND-1186) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for VS-4718 (PND-1186) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.