CAS No. 1061353-68-1

Batch: Purity:99.12
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VS-4718 (PND-1186) Chemical Structure
Chemical Structure
Check the VS-4718 (PND-1186) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide
CAS Number 1061353-68-1
Molecular Formula

C25H26F3N5O3
Molecular Weight (MW) 501.5
SMILES CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC
InChIKey IGUBBWJDMLCRIK-UHFFFAOYSA-N

Ordering Information

Biological Activity

VS-4718 (PND-1186) is a reversible and selective inhibitor of focal adhesion kinase (FAK) with an IC50 of 1.5 nM. By inhibiting FAK autophosphorylation at Tyr397, VS-4718 disrupts downstream focal adhesion signaling pathways. This inhibition reduces cell migration and invasion, selectively induces tumor cell apoptosis, and decreases tumor growth and metastasis in preclinical models.

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (199.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.