Volasertib (BI6727) is a potent, highly specific, ATP-competitive PLK1 inhibitor. It affects PI3K/AKT/mTOR and AURKA-PLK1-FOXM1 signaling pathways by inducing G2/M cell cycle arrest, promoting DNA damage, and downregulating MYC, effectively inhibiting tumor cell proliferation and promoting apoptosis.
Volasertib (BI6727) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Volasertib (BI6727) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.