Vitamin E Clinical Trials

Size	Price	Qty
100mg	USD 147
500mg	USD 297

Clinical Trials

Numerous clinical trials evaluate Vitamin E across a diverse spectrum of medical conditions, including type 2 diabetes mellitus, cardiovascular diseases, non-alcoholic steatohepatitis, anemia, and micronutrient deficiencies. These studies encompass Early Phase 1 through Phase 4, alongside observational and nutritional intervention designs, with recruitment statuses spanning completed, recruiting, terminated, and not yet recruiting. Research initiatives are sponsored by a wide range of entities, including academic universities, medical centers, and global philanthropic foundations such as the Bill and Melinda Gates Foundation.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05175300	RECRUITING	Hip Arthropathy	GCS Ramsay Santé pour l'Enseignement et la Recherche	2023-03-24
NCT07303803	RECRUITING	MASH - Metabolic Dysfunction-Associated Steatohepatitis; T2DM (Type 2 Diabetes Mellitus)	Shanghai Jiao Tong University School of Medicine	2026-01-01	PHASE2
NCT07668284	NOT_YET_RECRUITING	Prostate Cancer; Uterine Cancer; Cervical Cancer; Anal Cancer	University of Nebraska	2026-07-01	PHASE1; PHASE2
NCT07715890	NOT_YET_RECRUITING	Lipid Metabolism Disorders	National Heart, Lung, and Blood Institute (NHLBI)	2026-09-09
NCT07796204	NOT_YET_RECRUITING	Obesity; Type 2 Diabetes	Pennington Biomedical Research Center	2026-09-03
NCT07781514	ENROLLING_BY_INVITATION	Hypothyroidism	Bangladesh Medical University	2027-02
NCT06321991	RECRUITING	Dupuytren's Disease	Universitaire Ziekenhuizen KU Leuven	2024-02-15	PHASE2
NCT06915701	RECRUITING	Rheumatoid Arthritis	University of Guadalajara	2026-02-06	PHASE2; PHASE3
NCT07312123	RECRUITING	Carpal Tunnel Syndrome	Hospital Universiti Sains Malaysia	2025-12-08
NCT05573204	ACTIVE_NOT_RECRUITING	Non-alcoholic Steatohepatitis	Tanta University	2021-09-01	PHASE2
NCT06519097	ACTIVE_NOT_RECRUITING	Neoplasm of Pancreas; IPMN, Pancreatic	H. Lee Moffitt Cancer Center and Research Institute	2024-07-09	PHASE2
NCT02966665	RECRUITING	Chronic Obstructive Pulmonary Disease; Pulmonary Artery Hypertension; Heart Failure; Hypertension	Russell Richardson	2008-09	PHASE1
NCT06926712	NOT_YET_RECRUITING	Respiratory Disease	Assiut University	2025-06	PHASE4
NCT05574036	ACTIVE_NOT_RECRUITING	Non Alcoholic Steatohepatitis; Hyperuricemia	Tanta University	2022-08-25	PHASE2
NCT06950736	NOT_YET_RECRUITING	Infertility Female	The First Affiliated Hospital of Zhengzhou University	2025-05-05
NCT07331103	RECRUITING	Cardiovascualr Disease; Lipids; Inflammation; n-3 Polyunsatured Fatty Acids (n-3 PUFA)	Mario Negri Institute for Pharmacological Research	2025-11-26
NCT06847880	COMPLETED	Pain Perception; Root Resorption; Rate of Orthodontic Tooth Movement; Biomarkers	University of Baghdad	2025-02-27	PHASE1
NCT07723443	COMPLETED	PCOS (Polycystic Ovary Syndrome)	Al-Mustansiriyah University	2025-07-01
NCT07466342	COMPLETED	Dysmenorrhea Primary; Vitamin E; Mefenamic Acid	Nishtar Medical University	2025-07-15	PHASE4
NCT06871904	COMPLETED	Oral Submucous Fibrosis	Ziauddin University	2025-04-07	PHASE1; PHASE2
NCT05771181	RECRUITING	Colorectal Cancer; Microsatellite Stable Colorectal Carcinoma	Fudan University	2023-03-01	PHASE2
NCT01871454	UNKNOWN	Non-small Cell Lung Cancers	University of Louisville	2013-10	PHASE2
NCT06775548	ENROLLING_BY_INVITATION	Depression Disorders	Ziauddin University	2024-09-02
NCT05939726	COMPLETED	Palmar-Plantar Erythrodysesthesia; Palmar-Plantar Erythrodysesthesia Due to Cytotoxic Therapy	Sarawak General Hospital	2023-05-16
NCT02107976	COMPLETED	Diabetes Type 2	National Institutes of Health Clinical Center (CC)	2019-06-14
NCT04801849	COMPLETED	Nonalcoholic Fatty Liver Disease; Nonalcoholic Steatohepatitis	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2022-08-05	PHASE2
NCT05616442	COMPLETED	Hepatic Disease	Tanta University	2023-05-20	PHASE4
NCT06901076	COMPLETED	Perimenopausal Disorder; Impaired Glucose Tolerance; Impaired Fasting Glycemia	Fondazione IRCCS Policlinico San Matteo di Pavia	2024-03-12
NCT07022938	COMPLETED	Cancer; Neuropathy; Chemotherapy Induced Pain Neuropathy; Chemotherapy-Induced Peripheral Neuropathy	Aristotle University Of Thessaloniki	2021-11-01	PHASE4
NCT06623227	ENROLLING_BY_INVITATION	Autism Spectrum Disorder	Rinvil Renaldi	2024-09-28
NCT06571721	UNKNOWN	Collagen Degeneration; Wrinkle; Pigmentation; Elastic Skin; Sebum Deficiency	Integrative Skin Science and Research	2024-07-22
NCT06100432	ACTIVE_NOT_RECRUITING	Male Infertility	Duta Wacana Christian University	2023-11-11	PHASE4
NCT05343611	UNKNOWN	Dementia; Dementia, Mild; Dementia Moderate; Dementia Senile; Malnutrition; Deficiency Nutritional; Deficiency Diseases	Massimo Venturelli, PhD	2022-05-01
NCT04007874	UNKNOWN	Migraine; Migraine;Menstrual	Leiden University Medical Center	2019-09-10	PHASE3
NCT06677788	COMPLETED	Non-Alcoholic Steatohepatitis (NASH)	Tanta University	2022-04-01	PHASE2
NCT05410093	UNKNOWN	Primary Ovarian Insufficiency	Affiliated Hospital of Nantong University	2022-02-01
NCT04287816	COMPLETED	Nutritional Requirements	Ohio State University	2021-06-01
NCT06596382	COMPLETED	Non-Alcoholic Fatty Liver Disease	National University of Malaysia	2020-10-13
NCT06105060	COMPLETED	Non-alcoholic Steatohepatitis	Beni-Suef University	2023-12-17	EARLY_PHASE1
NCT03228238	TERMINATED	Variant Angina	Seoul National University Hospital	2014-09-01	PHASE4
NCT06373848	ENROLLING_BY_INVITATION	Periodontal Diseases	Islamic Azad University, Sanandaj	2024-03-20
NCT06323538	Not yet recruiting	Dietary Exposure\|Diabetes Mellitus Type 2\|Cardiovascular Diseases\|Bone Loss\|Sustainability\|Exposure\|Obesity\|Vitamin Deficiency\|Mineral Deficiency	German Federal Institute for Risk Assessment\|Max Rubner-Institut\|University of Bonn\|Research Institute for Plant-Based Nutrition\|University of Jena\|University of Regensburg\|Heidelberg University\|University of Vienna	2024-04-01	--
NCT06319079	Not yet recruiting	Lactating Mothers\|Infants	Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri	2024-03	Not Applicable
NCT06081257	UNKNOWN	Diminished Ovarian Reserve	Women's Hospital School Of Medicine Zhejiang University	2023-10-15
NCT05610683	COMPLETED	End Stage Renal Disease (ESRD)	Poitiers University Hospital	2023-06-14
NCT06058442	Recruiting	Gastrectomy	University of Leipzig	2024-01-24	Phase 3
NCT05941949	UNKNOWN	Dietary Supplement; Cognition; Healthy	Pharmanex	2023-07-05
NCT07104786	COMPLETED	Non Alcoholic Fatty Liver Disease	King Edward Medical University	2023-08-24	PHASE2
NCT06057597	Recruiting	Obesity\|Morbid	Assistance Publique - Hôpitaux de Paris	2023-11-13	Not Applicable
NCT05906498	UNKNOWN	Psoriasis Vulgaris	Badr University	2022-12-01	PHASE3
NCT03916068	TERMINATED	Breast Cancer	Legacy Health System	2019-07-01	PHASE2
NCT06081114	Recruiting	Micronutrient Status	Johns Hopkins Bloomberg School of Public Health\|International Center for Diarrheal Disease Research Bangladesh (icddrb)\|Bill and Melinda Gates Foundation	2023-10-22	Not Applicable
NCT06211478	COMPLETED	Gaucher Disease	Ain Shams University	2023-03-03	PHASE3
NCT04704063	COMPLETED	Hepatic Steatosis; NAFLD	Yuen Kah Hay	2021-01-01	PHASE2
NCT05604300	COMPLETED	Metabolic Syndrome	Universiti Sains Malaysia	2022-06-01
NCT03903133	COMPLETED	Sickle Cell Disease	Ain Shams University	2016-06-01	PHASE4
NCT05787925	COMPLETED	Lichen Planus	Hams Hamed Abdelrahman	2022-10-20
NCT04984798	WITHDRAWN	Hyperinsulinism-Hyperammonemia Syndrome	Children's Hospital of Philadelphia	2022-11	PHASE2
NCT07715643	COMPLETED	Nephrolithiasis; Calcium Oxalate Kidney Stones	University of Lahore	2022-12-05
NCT04312152	UNKNOWN	Autism Spectrum Disorder; Phelan-McDermid Syndrome	Antonio Persico	2019-03-09
NCT05402826	COMPLETED	Heart Surgery	Shahid Beheshti University	2022-06-06
NCT05984173	COMPLETED	Dry Socket	Ain Shams University	2022-01-01	PHASE4
NCT00551967	UNKNOWN	Osteoarthritis of Hip; Traumatic Arthritis of Hip	Massachusetts General Hospital	2007-10
NCT06574711	COMPLETED	Cardiovascular Diseases; Apolipoproteins; Food Preferences; Low-density-lipoprotein-type; HDL; Triglycerides; Functional Food	Pontificia Universidad Javeriana	2022-03-22
NCT03830164	COMPLETED	Male Erectile Disorder; Prostate Adenocarcinoma; Erectile Dysfunction, CTCAE; Impotence	M.D. Anderson Cancer Center	2019-11-20	PHASE2
NCT05200663	UNKNOWN	Oligoasthenoteratozoospermia; Male Infertility	Sharif Medical Research Center	2021-10-15	PHASE2
NCT06509581	COMPLETED	Beta-Thalassemia	Ain Shams University	2021-07-05
NCT04198805	COMPLETED	Non-Alcoholic Fatty Liver Disease; Non-Alcoholic Fatty Liver; Non-Alcoholic Steatohepatitis	Naga P. Chalasani	2020-01-03	PHASE2
NCT04564690	UNKNOWN	n-3 Polyunsaturated Fatty Acids; Selenium; Vitamin E; Lutein	Josip Juraj Strossmayer University of Osijek	2020-10-01
NCT02827747	WITHDRAWN	Keratoconus	University of Miami	2021-08-01	PHASE2
NCT03557229	UNKNOWN	Oxidative Stress; Septic Shock	American British Cowdray Medical Center	2018-07-23	PHASE3
NCT05151055	UNKNOWN	Hormonal Acne	United Laboratories	2020-03-02	PHASE2
NCT03611530	TERMINATED	Open Angle Glaucoma	Mario Negri Institute for Pharmacological Research	2017-09-04
NCT06274216	COMPLETED	Osseointegration Failure of Dental Implant	Ziauddin University	2021-09-01
NCT06391411	COMPLETED	Age-Related Macular Degeneration	Azienda Ospedaliero-Universitaria Careggi	2021-03-01
NCT05488925	COMPLETED	Symptomatic Irreversible Pulpitis	Farjad Zafar	2021-06-21	PHASE4
NCT05127928	COMPLETED	Oxidative Stress	Universidad Europea de Madrid	2022-02-10
NCT04481841	UNKNOWN	Burning Mouth Syndrome; Oral Mucosa Disease	Second Affiliated Hospital, Zhejiang University, School of Medicine	2020-07-27	EARLY_PHASE1
NCT03971604	UNKNOWN	Preeclampsia; Vitamin A Deficiency; Vitamin E Deficiency	Second Affiliated Hospital, Zhejiang University, School of Medicine	2019-01-01
NCT05905185	COMPLETED	Obesity	National University of Malaysia	2020-01-01	PHASE4
NCT03582384	WITHDRAWN	Short Bowel Syndrome; Vitamin E Deficiency	Boston Children's Hospital	2020-12	PHASE2
NCT02814695	COMPLETED	Infertility, Male	Benha University	2020-08-15	PHASE1
NCT03176966	COMPLETED	Muscle Cramp; Cirrhosis	Vanderbilt University Medical Center	2016-09-02	PHASE4
NCT04193982	UNKNOWN	NAFLD	Asian Institute of Gastroenterology, India	2021-01-31	PHASE3
NCT05660694	COMPLETED	Triamcinolone; Pentoxifylline; Vitamin E; Oral Submucosa Fibrosis; Tumor	Altamash Institute of Dental Medicine	2020-01-01	PHASE4
NCT07412574	COMPLETED	COVID - 19	Universidad Veracruzana	2020-09-27	EARLY_PHASE1
NCT00392561	COMPLETED	Non-melanoma Skin Cancer	University of Chicago	2006-04-01
NCT06200584	COMPLETED	Antipsychotics and Neuroleptics Toxicity	Dr Rabia Arshad	2021-01-01
NCT04828642	COMPLETED	Hypertrophy	Universidad Europea de Madrid	2021-02-01
NCT03669133	TERMINATED	NAFLD; NASH - Nonalcoholic Steatohepatitis; HIV Infections	Indiana University	2019-10-01	PHASE2
NCT04713332	UNKNOWN	Radiation-induced Injuries in Patients With Rectal Cancer	University of Jordan	2019-07-06	PHASE3
NCT04509583	COMPLETED	Infertility, Male	Hue University of Medicine and Pharmacy	2019-11-18
NCT04694027	UNKNOWN	Mastalgia	Cairo University	2021-01	PHASE4
NCT05019768	COMPLETED	Keratoconus	Ciro Caruso	2017-09-01
NCT04570254	COMPLETED	Pneumonia, Viral; Covid19; ARDS; Oxidative Stress	Unidad Temporal COVID-19 en Centro Citibanamex	2020-08-19
NCT02962297	COMPLETED	NASH (Non-Alcoholic Steatohepatitis)	Zhejiang Medicine Co., Ltd.	2016-12
NCT04362384	UNKNOWN	Bleeding Anal; Pain; Stings	Hospital General Universitario Elche	2020-05-01	PHASE3
NCT04463459	UNKNOWN	Breast Cancer	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2019-10-10
NCT04315909	UNKNOWN	Diabetic Foot Ulcers; Diabetic Wound	Mashhad University of Medical Sciences	2019-08-28	PHASE2; PHASE3
NCT03613389	UNKNOWN	Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy	Cairo University	2020-01-01
NCT04977661	COMPLETED	Nonalcoholic Steatohepatitis (NASH)	Kafrelsheikh University	2020-02-01	PHASE4
NCT04140136	UNKNOWN	Amyotrophic Lateral Sclerosis	University of Malaya	2019-06-17	PHASE2
NCT04723849	COMPLETED	Childhood Obesity	Universita di Verona	2019-02-01
NCT03797222	COMPLETED	Hyperinsulinism-Hyperammonemia Syndrome	Elizabeth A Rosenfeld	2019-04-15
NCT05734235	COMPLETED	Ultraviolet B Radiation; Microvesicle Particles	Wright State University	2018-07-16	PHASE1
NCT03755700	UNKNOWN	Coronary Artery Disease; Coronary Artery Angiography; Coronary Catheterization; Contrast-induced Nephropathy; Stable Angina; Acute Coronary Syndrome	Rajaie Cardiovascular Medical and Research Center	2018-11-01	PHASE3
NCT03294967	COMPLETED	High Myopia; Choroid	The Hong Kong Polytechnic University	2017-09-01
NCT04000789	UNKNOWN	Non-Proliferative Diabetic Retinopathy; Proliferative Diabetic Retinopathy New Vessels on Disc; Dry Eye Syndromes	Dr Cipto Mangunkusumo General Hospital	2019-07
NCT04215432	COMPLETED	Peri-implant Mucositis	Universidad Complutense de Madrid	2018-05-01
NCT02254980	ACTIVE_NOT_RECRUITING	Total Hip Arthroplasty	Danderyd Hospital	2013-02
NCT01792115	COMPLETED	Fatty Liver	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2013-05-01	PHASE2
NCT03668964	COMPLETED	Healthy Volunteers	dsm-firmenich Switzerland AG	2018-08-20
NCT02193022	COMPLETED	Post Kala Azar Dermal Leishmaniasis	International Centre for Diarrhoeal Disease Research, Bangladesh	2014-07	PHASE3
NCT04126421	COMPLETED	Total Hip Arthroplasty (THA)	Oslo University Hospital	2011-04-01
NCT03765827	COMPLETED	Postoperative Pain	Hospital General Universitario Elche	2018-12-05	PHASE3
NCT03674385	COMPLETED	Clomiphene Citrate Resistant Polycystic Ovary Syndrome	Ain Shams University	2018-07-19	PHASE2
NCT03988725	COMPLETED	HIV Mono Infection	McGill University Health Centre/Research Institute of the McGill University Health Centre	2014-11-11
NCT03787030	COMPLETED	Pain	Hospital General Universitario Elche	2018-12-21	PHASE3
NCT02310087	COMPLETED	Infertility, Male	University Medical Centre Ljubljana	2014-11
NCT03594708	UNKNOWN	Ulcerative Colitis	Baptist Memorial Health Care Corporation	2018-04-30
NCT02263924	UNKNOWN	Ischemic Stroke	Seberang Jaya Clinical Research Centre	2015-07	PHASE3
NCT01578629	COMPLETED	Ischemic Stroke; Transient Ischemic Attack (TIA)	Andrew Slivka	2012-03	PHASE1; PHASE2
NCT03489759	UNKNOWN	Renal Failure; Renal Insufficiency, Acute	St. Bortolo Hospital	2018-03-13
NCT03476564	UNKNOWN	Infertility, Female	Benha University	2018-05-01	EARLY_PHASE1
NCT00700791	TERMINATED	Scar	Chandan K Sen	2008-07	EARLY_PHASE1
NCT02397486	COMPLETED	Head and Neck Neoplasms	Ain Shams University	2015-05-02	PHASE2
NCT03218865	COMPLETED	End Stage Renal Disease; Inflammation	Hemotech	2013-10-16
NCT02776397	UNKNOWN	Diabetes Mellitus	Tan Tock Seng Hospital	2015-06
NCT02842567	COMPLETED	NAFLD	Bambino Gesù Hospital and Research Institute	2017-04-01	PHASE3
NCT03443141	UNKNOWN	Surgical Site Infection	Hospital General Universitario Elche	2018-01-01	PHASE3
NCT03271164	COMPLETED	Post-surgical Wounds	KLOX Technologies Inc.	2017-08-29
NCT03358524	COMPLETED	Obesity, Adolescent; Oxidative Stress	Indonesia University	2017-09-28	PHASE4
NCT00798876	COMPLETED	Prostate Cancer	Jonsson Comprehensive Cancer Center	2001-12-18
NCT01754155	UNKNOWN	Radiostereometric Analysis; Vitamin E Liner; Zimmer® Continuum® Acetabular Cup	Central DuPage Hospital	2013-01
NCT02793648	COMPLETED	Depression	Yolanda de Diego Otero	2014-10	PHASE2
NCT00784225	COMPLETED	Cataract; Macular Degeneration	SWOG Cancer Research Network	2004-07	PHASE3
NCT04640324	COMPLETED	Non-Alcoholic Fatty Liver Disease; Insulin Resistance	University of Campania Luigi Vanvitelli	2017-01-16
NCT02942498	COMPLETED	X Fragile Syndrome	Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud	2016-07	PHASE3
NCT01749371	COMPLETED	Burn	The University of Texas Medical Branch, Galveston	2013-02	PHASE2; PHASE3
NCT01413620	WITHDRAWN	Burn Injury	Shriners Hospitals for Children	2011-08	PHASE1
NCT04126720	COMPLETED	Oral Lichen Planus	Cairo University	2016-01-22	PHASE1
NCT02407548	COMPLETED	Dyslipidemia	Sun Yat-sen University	2015-07	PHASE3
NCT02629536	UNKNOWN	Migraine, Headaches	University of Notre Dame Australia	2016-03	PHASE3
NCT01508221	COMPLETED	Brain Metastasis	University of Cincinnati	2011-06	PHASE2
NCT02690792	COMPLETED	Healthy; NAFLD (Non-Alcoholic Fatty Liver Disease); NASH (Non-Alcoholic Steatohepatitis)	Jeffrey Browning	2009-12
NCT01720719	UNKNOWN	Fatty Liver; Dyslipidemias; Diabetes Mellitus	Xin Gao	2013-05	PHASE4
NCT02758990	TERMINATED	Obesity; Rhinitis; Rhinitis, Allergic; Respiratory Sounds; Dyspnea; Headache; Migraine Disorders; Arthritis; Arthralgia; Anxiety; Sleep Initiation and Maintenance Disorders; Sleep Deprivation	Verifomics LLC	2016-03
NCT02922491	COMPLETED	Obesity	Federal University of Paraíba	2016-06-01
NCT02524587	UNKNOWN	Total Hip Replacement	University Hospital, Caen	2010-01
NCT00862433	COMPLETED	Diabetes; Fatty Liver; Obesity; Healthy Volunteers	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2014-10-10	PHASE1
NCT01002547	COMPLETED	Nonalcoholic Steatohepatitis	VA Office of Research and Development	2010-06-24	PHASE4
NCT01904591	COMPLETED	Spinal Cord Injury	McMaster University	2013-10
NCT02820948	COMPLETED	Surgical Site Infection	Hospital General Universitario Elche	2015-01	PHASE3
NCT02468518	COMPLETED	Chronic Arsenic Poisoning	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2015-03	PHASE2
NCT03313869	COMPLETED	Metabolic Disturbance; Glucose Intolerance; Physical Inactivity; Glucose Metabolism Disorders; Lipid Metabolism Disorders; Oxidative Stress	Centre National d'Etudes Spatiales	2015-06
NCT03274596	COMPLETED	Retinopathy of Prematurity	Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes	2013-03-01
NCT00706121	COMPLETED	Colorectal Cancer; Precancerous Condition	SWOG Cancer Research Network	2008-06	PHASE3
NCT02554123	COMPLETED	Pain	Hospital General Universitario Elche	2015-01	PHASE3
NCT01457690	COMPLETED	Hypobetalipoproteinemias	Hospices Civils de Lyon	2011-10	PHASE3
NCT00840112	TERMINATED	Peripheral Neuropathy; Mitochondrial Trifunctional Protein Deficiency	Oregon Health and Science University	2010-07
NCT00985777	COMPLETED	Pancreatic Neoplasms	H. Lee Moffitt Cancer Center and Research Institute	2009-09	PHASE1
NCT02070679	COMPLETED	Stable Angina; Unstable Angina; Non ST Segment Elevation Myocardial Infarction; Post MI	Urmia University of Medical Sciences	2014-02	PHASE3
NCT01329770	COMPLETED	Fragile X Syndrome	Yolanda de Diego Otero	2010-12	PHASE2
NCT02011906	UNKNOWN	Coronary Artery Disease	Tehran University of Medical Sciences	2013-10	PHASE4
NCT01284049	COMPLETED	Liver Diseases	Assistance Publique - Hôpitaux de Paris	2011-11
NCT02178839	UNKNOWN	Non Alcoholic Fatty Liver Disease	Urmia University of Medical Sciences	2014-07
NCT01897792	TERMINATED	Coagulopathy; Nosocomial Pneumonia	University of Alabama at Birmingham	2013-05	PHASE2
NCT01846325	COMPLETED	Asthenozoospermia	National Nutrition and Food Technology Institute	2013-12	PHASE2; PHASE3
NCT01787591	COMPLETED	Non-alcoholic Fatty Liver; Metabolic Syndrome	Ohio State University	2013-04
NCT02019186	COMPLETED	Type 1 Diabetes Mellitus	Nationwide Children's Hospital	2013-12	PHASE4
NCT02087033	TERMINATED	Arrhythmia	IRCCS Policlinico S. Donato	2013-12
NCT01934777	COMPLETED	Fatty Liver; Liver Fibrosis; Obesity; Metabolic Syndrome; Nonalcoholic Fatty Liver Disease	Bambino Gesù Hospital and Research Institute	2013-10	PHASE3
NCT02163070	COMPLETED	Chronic Kidney Disease	Mohammad Hassan Eftekhari	2013-09	PHASE2
NCT01984567	UNKNOWN	Oxidative Stress	Maastricht University Medical Center	2013-04
NCT01473914	COMPLETED	End Stage Renal Disease	Marcello Tonelli	2012-11	PHASE3
NCT00844792	COMPLETED	Cancer of the Prostate; Prostate Cancer; Prostatic Neoplasms	University Health Network, Toronto	2008-10	PHASE2
NCT01098994	COMPLETED	Type 1 Diabetes; Heart Disease	University of Pittsburgh	2010-02
NCT00744549	COMPLETED	Cancer of the Prostate; Prostate Cancer; Prostatic Neoplasms	University Health Network, Toronto	2008-05	PHASE2
NCT01384578	WITHDRAWN	Non Alcoholic Steatohepatitis	Institute of Liver and Biliary Sciences, India	2011-07	PHASE3
NCT01495260	COMPLETED	Adrenomyeloneuropathy	Pujol, Aurora, M.D.	2011-09	PHASE2
NCT01927679	COMPLETED	Pigmentation From Visible Light	Innovaderm Research Inc.	2013-08
NCT01735097	COMPLETED	Arsenical Keratosis	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2013-01
NCT02058212	COMPLETED	Endometriosis	Cairo University	2013-03	PHASE2
NCT01743742	COMPLETED	Birth Asphyxia	Sir Takhtasinhji General Hospital	2013-05	PHASE4
NCT01700426	COMPLETED	Iron Deficiency; Iron Deficiency Anemia	University of Colorado, Denver	2011-06	PHASE1
NCT01082003	UNKNOWN	Capsular Contractures	Legacy Health System	2009-10
NCT01578473	COMPLETED	Peyronie's Disease	Men's Health Boston	2013-05-23	PHASE1
NCT01957319	COMPLETED	Work Ability; Depression	University of Catania	2010-02	PHASE3
NCT00905918	COMPLETED	Colorectal Cancer	Rutgers, The State University of New Jersey	2009-06	PHASE1
NCT01661530	COMPLETED	Asthma	University of Aberdeen	2012-12
NCT01463735	COMPLETED	Cirrhosis	University Hospital, Geneva	2011-11	PHASE2
NCT01450046	COMPLETED	Pancreatic Cancer	H. Lee Moffitt Cancer Center and Research Institute	2011-10	PHASE1
NCT02441530	COMPLETED	Primary Dysmenorrhoea	Bezmialem Vakif University	2012-11	PHASE3
NCT01671254	COMPLETED	Hyperlipidemia	MetaProteomics LLC	2012-08
NCT01935817	COMPLETED	Liver Fibrosis	University of Catania	2010-06	PHASE3
NCT00235716	COMPLETED	Alzheimer's Disease	US Department of Veterans Affairs	2007-08	PHASE3
NCT01446952	COMPLETED	Pancreatic Cancer	H. Lee Moffitt Cancer Center and Research Institute	2011-09	PHASE1
NCT01554345	UNKNOWN	Acute Kidney Injury	Tehran University of Medical Sciences	2011-06	PHASE2
NCT00678834	COMPLETED	End Stage Cardiac Failure; Pulmonary Failure; End Stage Liver Disease; Morbid Obesity; Recalcitrant Epilepsy Requiring Surgery; Healthy Subjects	Chandan K Sen	2006-03	EARLY_PHASE1
NCT01316081	COMPLETED	Metabolic Syndrome	Swiss Federal Institute of Technology	2011-03
NCT00895115	COMPLETED	Prostate Cancer	University of Medicine and Dentistry of New Jersey	2009-04	PHASE1
NCT00056329	UNKNOWN	Down Syndrome; Alzheimer Disease	New York State Institute for Basic Research	2002-04	PHASE3
NCT01279434	WITHDRAWN	Non Alcoholic Steatohepatitis	Institute of Liver and Biliary Sciences, India	2012-01
NCT00753532	COMPLETED	Cerebrovascular Disorders	Universiti Sains Malaysia	2007-11	PHASE2
NCT01369043	TERMINATED	Exercise and Non-exercise Effect Upon Vitamins E and C	USDA Grand Forks Human Nutrition Research Center	2011-05
NCT01148576	UNKNOWN	Chronic Hepatitis B; Hepatic Steatosis	Zhejiang University	2010-06	PHASE4
NCT02248584	COMPLETED	Skin Neoplasms	University of Campinas, Brazil	2011-01
NCT01752972	COMPLETED	Arsenical Keratosis	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2011-04
NCT02801019	COMPLETED	Osteoarthritis	Sahlgrenska University Hospital	2008-06
NCT02132091	COMPLETED	Aging; Metabolism	University of Florida	2011-03
NCT01266928	COMPLETED	Preterm Premature Rupture of Membranes	Erzincan Military Hospital	2011-01	PHASE3
NCT02181348	COMPLETED	Anemia	Aga Khan University	2008-11	PHASE1; PHASE2
NCT02980094	COMPLETED	Nutrient Deficiency; Age-Related Immunodeficiency; Vitamin E Deficiency; Selenium Deficiency; Fatty Acid Deficiency; Institutionalization; Disinhibited Attachment	Eduardo Ferriolli	2011-08
NCT01410084	COMPLETED	Vitamin D Deficiency; Accidental Falls	Wake Forest University Health Sciences	2010-10
NCT01193270	COMPLETED	Infant, Newborn; Infant, Small for Gestational Age; Infant, Very Low Birth Weight; Infant, Premature; Intracranial Hemorrhages	NICHD Neonatal Research Network	2010-10	PHASE1
NCT00740714	TERMINATED	Parkinson Disease	Weill Medical College of Cornell University	2008-12	PHASE3
NCT01597765	COMPLETED	Thalassemia	Mahidol University	2009-06
NCT00270647	COMPLETED	Cancer; Prostate Cancer; Colorectal Cancer; Cardiovascular Disease; Eye Disease; Cognitive Decline	Brigham and Women's Hospital	1997-07
NCT01743066	COMPLETED	Chronic Arsenic Poisoning	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2010-10
NCT00006392	COMPLETED	Prostate Cancer	SWOG Cancer Research Network	2001-07	PHASE3
NCT00363129	COMPLETED	Neurotoxicity; Unspecified Adult Solid Tumor, Protocol Specific	Alliance for Clinical Trials in Oncology	2006-12	PHASE3
NCT00152815	TERMINATED	HIV Infections; Fatty Liver	Johane Allard	2003-10	PHASE2
NCT01147523	COMPLETED	Fatty Liver; Steatohepatitis	Aristotle University Of Thessaloniki	2010-01	PHASE2
NCT01152931	COMPLETED	Malaria	University of Lagos, Nigeria	2010-08	PHASE3
NCT01523574	COMPLETED	Peripheral Neuropathy	Felipe Melo Cruz	2009-08	PHASE2
NCT01188005	UNKNOWN	Obstructive Sleep Apnea Syndrome	University of Athens	2010-08
NCT00372879	COMPLETED	Amyotrophic Lateral Sclerosis	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	2006-12	PHASE3
NCT00063453	COMPLETED	Chronic Obstructive Pulmonary Disease; Lung Diseases; Lung Diseases, Obstructive	Cornell University	2003-08	PHASE3
NCT01113671	COMPLETED	Diabetes Mellitus Type 2	Technion, Israel Institute of Technology	2009-01	PHASE2; PHASE3
NCT00583700	COMPLETED	Fibrosis	University of Iowa	2003-02	PHASE2
NCT00809458	TERMINATED	Prostate Cancer	New Mexico Cancer Research Alliance	2008-09	PHASE3
NCT01594346	COMPLETED	Alzheimer's Disease; Down Syndrome	New York State Institute for Basic Research	2000-09	PHASE3
NCT01099163	COMPLETED	Type 2 Diabetes Mellitus	Shahid Beheshti University of Medical Sciences	2009-01
NCT01001845	COMPLETED	Hemodialysis; End Stage Renal Disease	Shiraz University of Medical Sciences	2009-06	PHASE2
NCT00994526	COMPLETED	Colorectal Cancer	Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement	2009-10
NCT00063635	COMPLETED	Fatty Liver	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2005-09	PHASE3
NCT00096356	COMPLETED	Breast Cancer; Fatigue	Wake Forest University Health Sciences	2004-08-27	PHASE1
NCT00817622	COMPLETED	Diabetes Mellitus	Tehran University of Medical Sciences	2007-01	PHASE4
NCT00063622	COMPLETED	Liver Diseases	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2005-01	PHASE3
NCT00152841	TERMINATED	Crohn's Disease; Ulcerative Colitis; Mild or Moderate Anaemia	University Health Network, Toronto	2002-06	PHASE2
NCT01125033	COMPLETED	Restless Legs Syndrome; Kidney Failure, Chronic	Shiraz University of Medical Sciences	2008-03	PHASE2; PHASE3
NCT00135707	COMPLETED	Preeclampsia	The George Washington University Biostatistics Center	2003-06	PHASE3
NCT00638560	COMPLETED	Obesity; Type 2 Diabetes	University of Leipzig	2008-03	PHASE1
NCT00064194	COMPLETED	Precancerous/Nonmalignant Condition; Prostate Cancer	NCIC Clinical Trials Group	2001-11-28	PHASE3
NCT00079963	COMPLETED	Cardiovascular Disease	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2004-04
NCT03182712	COMPLETED	Type2 Diabetes Mellitus	Federal University of Rio Grande do Sul	2007-02
NCT00754247	COMPLETED	Keloid; Hypertrophic Scar; Cicatrix, Hypertrophic	University of Miami	2006-03	PHASE4
NCT01909063	COMPLETED	Vitamin D Deficiency; Hypovitaminosis A; Vitamin E Deficiency	Boston University	2005-01
NCT00731926	COMPLETED	Exercise Tolerance	Seoul National University Hospital	2007-09	PHASE2; PHASE3
NCT00281307	TERMINATED	Rhinitis	Milton S. Hershey Medical Center	2005-12-07
NCT00117403	COMPLETED	Alzheimer's Disease	National Institute on Aging (NIA)	2006-01	PHASE1
NCT00275600	COMPLETED	Cyclical Breast Pain	Mayo Clinic	2003-01	PHASE2; PHASE3
NCT00228319	COMPLETED	Ovarian Cancer	Jeanne Drisko, MD, CNS, FACN	2002-10	PHASE1; PHASE2
NCT00386178	COMPLETED	Asthma	University of North Carolina, Chapel Hill	2006-10	PHASE1
NCT00362518	COMPLETED	Diabetes	University of New Mexico	2004-07	PHASE3
NCT00687258	COMPLETED	Anemia	A. Manzoni Hospital	2006-07	PHASE2
NCT00211562	TERMINATED	Schizophrenia	Augusta University	2005-10	PHASE3
NCT00515736	TERMINATED	Critically Ill Patients; Cardiac Surgery; Trauma; Subarachnoid Hemorrhage	Centre Hospitalier Universitaire Vaudois	2003-01	PHASE3
NCT00067899	COMPLETED	Smoking	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2000-09	PHASE2
NCT00000541	COMPLETED	Cardiovascular Diseases; Coronary Arteriosclerosis; Coronary Disease; Heart Diseases; Myocardial Infarction; Myocardial Ischemia	Brigham and Women's Hospital	1993-05	PHASE2
NCT00006349	COMPLETED	Cognitive/Functional Effects; Delirium; Depression; Lung Cancer; Radiation Toxicity	Alliance for Clinical Trials in Oncology	2001-02	PHASE3
NCT00054561	COMPLETED	Head and Neck Cancer	Eastern Cooperative Oncology Group	2003-11-26	PHASE3
NCT00000479	COMPLETED	Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Disease; Heart Diseases; Myocardial Infarction; Myocardial Ischemia; Vascular Diseases	Brigham and Women's Hospital	1992-09	PHASE3
NCT00000173	COMPLETED	Alzheimer Disease	National Institute on Aging (NIA)	1999-03	PHASE3
NCT00010699	COMPLETED	Cardiovascular Diseases	National Center for Complementary and Integrative Health (NCCIH)		PHASE2
NCT00003367	COMPLETED	Prostate Cancer	Memorial Sloan Kettering Cancer Center	1998-04	PHASE3
NCT00758914	COMPLETED	Respiratory Infection; Elderly	Tufts University	1997-05
NCT00114387	COMPLETED	Atherosclerosis	National Institute on Aging (NIA)	1996-07	PHASE2; PHASE3
NCT00553124	UNKNOWN	Bladder Cancer	University Hospital Birmingham	2005-12	PHASE3
NCT00010842	COMPLETED	Multiple Sclerosis	National Center for Complementary and Integrative Health (NCCIH)	1999-09	PHASE1; PHASE2
NCT00000161	UNKNOWN	Macular Degeneration; Cataract	National Eye Institute (NEI)	1993-08	PHASE3
NCT00272428	COMPLETED	Healthy	Institut National de la Santé Et de la Recherche Médicale, France	1994-10	PHASE3
NCT00003599	WITHDRAWN	Lung Cancer	M.D. Anderson Cancer Center		PHASE3
NCT00004637	COMPLETED	Epilepsy	National Center for Research Resources (NCRR)		PHASE4
NCT00003619	COMPLETED	Chronic Myeloproliferative Disorders; Leukemia; Myelodysplastic Syndromes; Thrombocytopenia	Drexel University College of Medicine	1998-02	PHASE1; PHASE2
NCT00000600	TERMINATED	Cardiovascular Diseases; Carotid Artery Diseases; Intracranial Arteriosclerosis; Cerebrovascular Disorders; Heart Diseases; Vascular Diseases; Atherosclerosis	National Heart, Lung, and Blood Institute (NHLBI)	1995-06	PHASE2
NCT00303160	UNKNOWN	Heliobacter Pylori Infection	University of Toronto	2006-03	PHASE4
NCT00022204	COMPLETED	Breast Cancer; Lymphedema	Royal Marsden NHS Foundation Trust	2000-01	PHASE2
NCT00311116	COMPLETED	Cancer	The Hospital for Sick Children	2002-07	PHASE2; PHASE3
NCT00399282	COMPLETED	Rheumatoid Arthritis	Shahid Beheshti University of Medical Sciences	2006-10	PHASE1
NCT00055042	COMPLETED	Macular Edema; Diabetes Mellitus	National Eye Institute (NEI)	2003-02	PHASE1
NCT00314379	COMPLETED	Cardiovascular Diseases	Technion, Israel Institute of Technology	2006-04	PHASE2; PHASE3
NCT00000539	COMPLETED	Arterial Occlusive Diseases; Cardiovascular Diseases; Heart Diseases; Vascular Diseases; Diabetes Mellitus	National Heart, Lung, and Blood Institute (NHLBI)	1992-09	PHASE3
NCT00027287	COMPLETED	Diabetes Mellitus; Macular Edema	National Eye Institute (NEI)	2001-11	PHASE1
NCT00553345	UNKNOWN	Bladder Cancer	University of Birmingham	2005-12	PHASE3
NCT00384618	TERMINATED	Chronic Kidney Disease	Amsterdam UMC, location VUmc	2001-05	PHASE4
NCT00498992	UNKNOWN	Dermatologic Complications; Unspecified Adult Solid Tumor, Protocol Specific	Ingalls Memorial Hospital	2006-07
NCT00162526	WITHDRAWN	Oral Mucositis	Hadassah Medical Organization	2005-12	PHASE2
NCT00000114	COMPLETED	Retinitis Pigmentosa	National Eye Institute (NEI)	1984-05	PHASE3
NCT00000555	COMPLETED	Cardiovascular Diseases; Coronary Arteriosclerosis; Coronary Disease; Heart Diseases; Myocardial Ischemia; Postmenopause	National Heart, Lung, and Blood Institute (NHLBI)	1996-08	PHASE3
NCT00188552	TERMINATED	Wounds and Injuries	University Health Network, Toronto	2002-07	PHASE2
NCT00037063	WITHDRAWN	HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00220831	TERMINATED	Diabetes; Myocardial Infarction; Cardiovascular Disease	Technion, Israel Institute of Technology	2005-04	PHASE2; PHASE3
NCT00021645	COMPLETED	Cystoid Macular Edema; Uveitis	National Eye Institute (NEI)	2001-07	PHASE1

(data from https://clinicaltrials.gov, updated on 2025-12-03)

Check the Vitamin E product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

As a lipid-soluble antioxidant, Vitamin E acts as a potent peroxyl radical scavenger, noncompetitively inhibits cyclooxygenase activity, and suppresses vascular endothelial growth factor (VEGF) gene transcription to prevent oxidative cell damage and suppress angiogenic signaling pathways. By mitigating lipid peroxidation and VEGF-driven downstream stress, this compound preserves membrane integrity and inhibits pathological cell proliferation, underscoring its therapeutic relevance in clinical trial conditions such as non-alcoholic steatohepatitis, cardiovascular diseases, and metabolic disorders.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).