Clinical Trials

Numerous clinical trials evaluate L-ascorbic acid across Early Phase 1 through Phase 4 interventions for diverse indications, including type 2 diabetes, hypertriglyceridemia, cardiovascular disease, and chronic pain. Encompassing completed, active, and pending recruitment statuses, these studies are sponsored by government institutes and academic medical centers. Specific evaluations assess clinical parameters such as pharmacokinetics in healthy volunteers, renal hemodynamics, oxidative stress, and post-surgical pain reduction.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06068543 SUSPENDED
Frailty; Inflammation
University of Rochester
2024-10-25 PHASE2
NCT07765667 NOT_YET_RECRUITING
Rectal Adenocarcinoma; High-Risk Cancer; MSS
Sixth Affiliated Hospital, Sun Yat-sen University
2026-09-01 PHASE2
NCT06968936 RECRUITING
Anemia; Iron Deficiencies; Cardiac Surgery
Second Affiliated Hospital, Zhejiang University, School of Medicine
2026-03-27
NCT06009744 RECRUITING
Enterocutaneous Fistulas
Hospital Juarez de Mexico
2023-08
NCT04150042 RECRUITING
Pancreatic Adenocarcinoma Metastatic; BRCA1 Mutation; BRCA2 Mutation; Pancreatic Acinar Cell Carcinoma; Pancreatic Ductal Adenocarcinoma; Pancreatic Cancer; Metastatic Pancreatic Cancer; Metastatic Pancreatic Ductal Adenocarcinoma; Breast Cancer Metastatic; Breast Cancer Stage IV; Pancreatic Cancer Stage IV; HER2-negative Breast Cancer; HER2 Negative Breast Carcinoma; Adenocarcinoma of the Breast; PALB2 Gene Mutation; Pancreas Cancer, Metastatic; Pancreas Cancer, Recurrent; Pancreas Cancer; Stage IV Pancreatic Cancer; Stage 4 Pancreatic Cancer
General Oncology, Inc.
2021-01-13 PHASE1
NCT07197749 NOT_YET_RECRUITING
Graft-versus-host-disease (GVHD); Gastrointestinal
Baylor College of Medicine
2026-11 EARLY_PHASE1
NCT06823999 NOT_YET_RECRUITING
Stroke; Bruises; Skin Lesions
Chiayi Christian Hospital
2025-08-01 PHASE4
NCT06012760 RECRUITING
Anemia; Iron Deficiency Anemia; Perioperative; Transfusion; Cardiac Surgery
Second Affiliated Hospital, Zhejiang University, School of Medicine
2025-01-04
NCT07151105 RECRUITING
Adequate Vitamin C Status; Inadequate Vitamin C Status
Ohio State University
2025-10-01
NCT05817851 RECRUITING
Cardiac Arrest
Centre Hospitalier de Bethune
2023-12-27 PHASE2
NCT06995586 NOT_YET_RECRUITING
Cardio-pulmonary Bypass; Cardiovascular Diseases; Omega-3 Polyunsaturated Fatty Acids; Omega-3 Supplementation; Vitamin C; Supplements; Postoperative Depression; Antioxidants; Lactulose; Postoperative; Optimal Medical Therapy; CABG; Coronary Artery Bypass Grafting; Prebiotics
Nicosia General Hospital
2026-09-01
NCT06710899 NOT_YET_RECRUITING
Urinary Tract Infections
University Hospitals of North Midlands NHS Trust
2027-01 EARLY_PHASE1
NCT07612345 NOT_YET_RECRUITING
Pyruvate Kinase Deficiency; Glucose 6 Phosphate Dehydrogenase Deficiency
University of Utah
2026-07-15 PHASE1
NCT07184866 NOT_YET_RECRUITING
Acute-on-Chronic Liver Failure (ACLF)
Institute of Liver and Biliary Sciences, India
2026-04
NCT06336902 RECRUITING
Metastatic Colorectal Adenocarcinoma; Stage IV Colorectal Cancer AJCC v8
University of Southern California
2025-01-15 PHASE1
NCT07310407 NOT_YET_RECRUITING
NAFLD
Ain Shams University
2026-01-01 PHASE2
NCT06794047 RECRUITING
Diminished Ovarian Reserve; IVF Outcomes
Peking University Third Hospital
2025-03-17
NCT06123715 RECRUITING
Chronic Pain; Knee Pain Chronic; Post Operative Pain
University Health Network, Toronto
2024-04-16 PHASE2
NCT07121036 RECRUITING
Vitamin C
Zhongnan Hospital
2025-03-30 PHASE1
NCT07677826 RECRUITING
Depigmentation Treatment; Depigmentation
Al-Azhar University
2026-03-02
NCT03849443 RECRUITING
Open Posterior Thoracolumbar Spinal Fusion Procedure
Rush University Medical Center
2019-08-26 EARLY_PHASE1
NCT06601283 RECRUITING
Pancreatic Cancer
Fudan University
2024-11-22 PHASE2; PHASE3
NCT07652346 NOT_YET_RECRUITING
Healthy; Suboptimal Vitamin C Levels; Adequate Vitamin C Levels
Qualia Life Sciences
2026-07
NCT07726745 NOT_YET_RECRUITING
Maximum Force; Strength Endurance; Mental Fatigue
Yunliang Zhang
2026-07-25
NCT07605676 RECRUITING
Iron Deficiency Anemia
Cairo University
2026-01-15 PHASE4
NCT05913180 RECRUITING
Catheter-Associated Urinary Tract Infection
American University of Beirut Medical Center
2023-09-19 PHASE2
NCT02966665 RECRUITING
Chronic Obstructive Pulmonary Disease; Pulmonary Artery Hypertension; Heart Failure; Hypertension
Russell Richardson
2008-09 PHASE1
NCT07585422 COMPLETED
Stress; Stress (Psychology)
K.G. Razumovsky Moscow State University of Technologies and Management
2026-05-22
NCT07388121 RECRUITING
Short Chain Fatty Acids Concentration in Stools; Gut Microbiota Diversity and Composition
University of Glasgow
2025-11-01
NCT07664657 NOT_YET_RECRUITING
Bioavailability and Pharmacokinetics
Sichuan Credit Pharmaceutical Co., Ltd.
2026-06
NCT07379216 RECRUITING
Skin Condition; Anti-Oxidative Stress
TCI Co., Ltd.
2026-01-24
NCT06840574 SUSPENDED
Skin Health; Skin Aging of Face and Hands; Healthy; Ecchymosis
Standard Process Inc.
2025-04-01
NCT07369232 COMPLETED
Oxygen; Hyperoxemia; Antioxidant; Cerebral Autoregulation; Oxidative Stress
Erasme University Hospital
2025-09-01
NCT06847880 COMPLETED
Pain Perception; Root Resorption; Rate of Orthodontic Tooth Movement; Biomarkers
University of Baghdad
2025-02-27 PHASE1
NCT07414693 RECRUITING
Pneumonia Childhood; Vitamin C; Hospital Stay Time
Children's Hospital and Institute of Child Health, Multan
2025-08-28 PHASE4
NCT07383974 RECRUITING
Healthy Volunteers; Dietary Supplementation; Skin Health; Health Status; Antioxidants
ChinaNorm
2025-11-03
NCT02735707 RECRUITING
Community-acquired Pneumonia, Influenza, COVID-19
UMC Utrecht
2016-04-11 PHASE3
NCT06794255 RECRUITING
Ageing
Peking University Third Hospital
2025-04-02
NCT07285109 COMPLETED
Healthy; Suboptimal Vitamin C Levels
Qualia Life Sciences
2025-12-23
NCT06897384 ACTIVE_NOT_RECRUITING
Severe Acute Pancreatitis
Ruijin Hospital
2025-03-01
NCT06967428 NOT_YET_RECRUITING
Vaccine Adverse Reaction; Post Acute Covid-19 Vaccination Syndrome
Independent Medical Alliance
2025-09-01 PHASE2
NCT06657521 NOT_YET_RECRUITING
Primary Stability of the Implants; Pain
Universidad de Granada
2025-01-01 EARLY_PHASE1
NCT05345899 COMPLETED
Lupus or SLE; Spondyloarthritis
Centre Hospitalier Universitaire de Nice
2022-06-08
NCT04516681 RECRUITING
Colorectal Cancer; Vitamin C; GLUT3
Fudan University
2024-12-01 PHASE3
NCT05842382 UNKNOWN
Pneumonia
Clinical Research Centre, Malaysia
2024-01-12 PHASE2
NCT06723626 RECRUITING
Septic Shock
Southeast University, China
2024-07-01
NCT04268849 RECRUITING
Iron Deficiency Anemia
Auerbach Hematology Oncology Associates P C
2020-02-27 PHASE3
NCT06384833 UNKNOWN
Rotator Cuff Tears
Mahidol University
2024-05-01 PHASE4
NCT06018883 UNKNOWN
Metastatic Pancreatic Adenocarcinoma
Fudan University
2023-08-20 PHASE3
NCT06018896 UNKNOWN
Metastatic Pancreatic Cancer; Terminal Cancer
Fudan University
2023-08-25 PHASE2
NCT06971315 COMPLETED
Pain, Acute
Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
2025-07-18
NCT07242066 COMPLETED
Blood Pressure
University of Nottingham
2024-11-25
NCT06788132 COMPLETED
Premature Rupture of Membranes; Fetal Complications
Ricardo A Gutierrez Ramirez, MD, MSc, FACOG
2025-01-30
NCT05407194 RECRUITING
Patellar Tendinopathy
Gelderse Vallei Hospital
2023-04-01
NCT07569627 COMPLETED
Exercise; Blood Flow Restriction (BFR) Training Effects; Supplement
University of Taipei
2022-08-01
NCT07061431 COMPLETED
Cardio-protection
Democritus University of Thrace
2024-10-01
NCT06262711 UNKNOWN
Healthy
University of East Anglia
2024-02
NCT06781970 RECRUITING
Endothelial Cell Loss, Corneal; Cataract and Intraocular Lens (IOL) Surgery
Indonesia University
2024-12-07
NCT06421688 UNKNOWN
Ascorbic Acid; Neurosurgical Procedures; Humans; Ventilator-Induced Lung Injury; Postoperative Complications
Qianfoshan Hospital
2024-06-01 PHASE2
NCT04511468 ACTIVE_NOT_RECRUITING
PreDiabetes; Nutrition
Indonesia University
2021-06-23 PHASE2
NCT07141823 COMPLETED
Narghile
Nora Tariq Mohammed
2024-10-15
NCT05194189 COMPLETED
Sepsis; Septic Shock
Zhujiang Hospital
2022-02-08 PHASE2
NCT04273880 UNKNOWN
Stress
University of British Columbia
2018-04-28 PHASE1
NCT04033107 UNKNOWN
Hepatocellular Cancer; Pancreatic Cancer; Gastric Cancer; Colorectal Cancer
Zhongnan Hospital
2020-07-01 PHASE2
NCT07071220 COMPLETED
Systemic Lupus Erythematosus (SLE)
Universitas Sriwijaya
2024-09-01
NCT07083622 COMPLETED
Systemic Lupus Erythematosus (SLE)
Universitas Sriwijaya
2024-09-01
NCT06354582 UNKNOWN
Obstetric Labor Complications; Fever
Kunyue Li
2024-04-15 PHASE4
NCT06372171 UNKNOWN
Nutrition, Healthy
National Yang Ming Chiao Tung University
2024-04
NCT04404387 UNKNOWN
Septic; Acute Respiratory Distress Syndrome
Assistance Publique - Hôpitaux de Paris
2022-07-22 PHASE3
NCT05975125 COMPLETED
Vitamin C Anemia; Pregnancy Anemia
Department of Medical Services Ministry of Public Health of Thailand
2023-06-28
NCT05842395 COMPLETED
Distal Radius Fracture; Vitamine c; Prophylaxis
Damascus University
2023-06-15 PHASE4
NCT05668663 COMPLETED
Deficiency, Vitamin C
Hospices Civils de Lyon
2023-01-09
NCT06345092 COMPLETED
TMJ Pain
Cairo University
2024-04-15
NCT06206759 Not yet recruiting
Hypertriglyceridemia
Meir Medical Center
2024-05-01 --
NCT07076108 COMPLETED
Vitamin C; Oral Administration; Erythropoietin; End-Stage Renal Disease; Regular Hemodialysis
Ain Shams University
2019-08-01
NCT06323538 Not yet recruiting
Dietary Exposure|Diabetes Mellitus Type 2|Cardiovascular Diseases|Bone Loss|Sustainability|Exposure|Obesity|Vitamin Deficiency|Mineral Deficiency
German Federal Institute for Risk Assessment|Max Rubner-Institut|University of Bonn|Research Institute for Plant-Based Nutrition|University of Jena|University of Regensburg|Heidelberg University|University of Vienna
2024-04-01 --
NCT05841303 UNKNOWN
Thin Gingival Biotype
Cairo University
2023-07-01 PHASE4
NCT05733078 UNKNOWN
Hypothyroidism; Primary Hypothyroidism; Vitamin C Deficiency
Dr Adnan Agha
2023-11-01 PHASE2
NCT05911698 UNKNOWN
Melasma
Khadija Qenawi
2023-10-28
NCT05561257 TERMINATED
Neuropathic Pain
Pascoe Pharmazeutische Praeparate GmbH
2020-07-20 PHASE2
NCT06148740 COMPLETED
Skin Health
Manuka Health
2023-11-09
NCT06262711 Not yet recruiting
Healthy
University of East Anglia|The Norfolk and Norwich University Hospitals NHS Foundation Trust|The Quadram Institute Clinical Research Facility
2024-02 Not Applicable
NCT06246240 UNKNOWN
Pregnancy Nausea and Vomiting
Hitit University
2023-10-08
NCT06244758 Recruiting
Type2diabetes
University of Erlangen-Nürnberg Medical School|Bayer
2024-01-18 Phase 3
NCT04046861 COMPLETED
Hyperlactatemia; Cardiac Disease; Bypass Complication; Valve Disease, Heart; Vitamin C
University Medical Centre Maribor
2023-03-01
NCT05350124 UNKNOWN
Restless Legs Syndrome; End Stage Renal Disease
King Abdulaziz University
2022-11 PHASE3
NCT06074367 UNKNOWN
Post Operative Atrial Fibrillation
Helwan University
2020-10-13 PHASE4
NCT05810233 UNKNOWN
Rhinitis, Allergic; Allergy
National University of Malaysia
2023-07-15
NCT03682029 UNKNOWN
Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia-1; Cytopenia
Rigshospitalet, Denmark
2017-11-21
NCT04796636 UNKNOWN
Sepsis, Severe; Septic Shock
Melbourne Health
2021-09-27 PHASE1
NCT04747795 COMPLETED
Sepsis; Septic Shock; Sepsis, Severe
Universitaire Ziekenhuizen KU Leuven
2021-06-01 PHASE3
NCT04553666 COMPLETED
Frailty; Inflammation
University of Rochester
2021-04-28 PHASE2
NCT05122481 WITHDRAWN
Hypovitaminosis; Vitamin C Abnormal
University of Aberdeen
2023-01-15
NCT05745636 COMPLETED
Skin Inflammation
Appalachian State University
2023-03-13
NCT06402890 COMPLETED
Diet; Food; Nutrition
Liverpool John Moores University
2021-07-01
NCT05754242 UNKNOWN
Liver Transplantation; Postreperfusion Syndrome; Ascorbic Acid
Hospital Universitario Ramon y Cajal
2020-11-17 PHASE2
NCT05427279 COMPLETED
Effect of Food Supplement
University of California, Davis
2022-10-05
NCT04472000 TERMINATED
Shoulder Stiffness
Lindenhofgruppe AG
2021-04-27 PHASE4
NCT04291508 COMPLETED
Acute Respiratory Distress Syndrome; Critical Illness; Respiratory Failure; Sepsis
Massachusetts General Hospital
2021-10-13 PHASE2
NCT03146962 COMPLETED
Colorectal Cancer; Pancreatic Cancer; Lung Cancer
Weill Medical College of Cornell University
2017-03-29 PHASE2
NCT05694975 UNKNOWN
Vitamin C; COVID-19 Pneumonia
Zhujiang Hospital
2023-01-13 PHASE2; PHASE3
NCT05608057 COMPLETED
Gingival Pigmentation
Hams Hamed Abdelrahman
2022-10-22
NCT04316390 COMPLETED
Higher Uric Acid Concentrations (>5,5 mg/dl); Healthy
University of Kiel
2022-07-15
NCT05281562 TERMINATED
Diabetes Mellitus; Diabetic Peripheral Neuropathy; Diabetic Foot Ulcer
Prisma Health-Midlands
2023-02-08 PHASE2; PHASE3
NCT07575789 COMPLETED
Jaundice
University of Lahore Hospital (ULH)
2023-03-03
NCT05598619 COMPLETED
Quality of Life
dsm-firmenich Switzerland AG
2022-07-01
NCT05975879 COMPLETED
Osteoarthritis, Knee; Osteoarthritis; Knee Osteoarthritis; Knee Arthritis; Knee Discomfort; Knee Pain Swelling; Knee Pain Chronic
NPO Petrovax
2022-05-31
NCT06224881 COMPLETED
Septic Shock
Cairo University
2021-12-01 PHASE4
NCT03592693 TERMINATED
Shock, Septic
University of Athens
2018-09-06 PHASE2
NCT03649633 TERMINATED
Septic Shock
University of Athens
2018-09-06 PHASE1; PHASE2
NCT03835286 WITHDRAWN
Septic Shock; Sepsis
Hospital Español de Mexico
2019-03-01 PHASE3
NCT05183880 WITHDRAWN
Healthy
University of Exeter
2021-11-26
NCT03433781 COMPLETED
Myelodysplastic Syndromes
NYU Langone Health
2018-05-01 PHASE1; PHASE2
NCT03613727 COMPLETED
Lymphoid Leukemia; Myeloid Leukemia; Monocytic Leukemia; Myelodysplasia
Virginia Commonwealth University
2018-10-01 PHASE2
NCT04664010 COMPLETED
COVID-19
Xi'an International Medical Center Hospital
2020-02-06
NCT04046094 ACTIVE_NOT_RECRUITING
Bladder Cancer
University of Kansas Medical Center
2019-10-17 PHASE1; PHASE2
NCT03988257 COMPLETED
Diarrhoea;Acute
Medical University of Warsaw
2019-06-24 PHASE4
NCT04401150 COMPLETED
Vitamin C; COVID-19; Hospitalized Patients
Université de Sherbrooke
2020-08-14 PHASE3
NCT05192213 TERMINATED
Sepsis; Septic Shock
Hospital Sirio-Libanes
2021-08-01 PHASE3
NCT05310760 COMPLETED
Nutritional Rickets; Bone Turnover Rate Disorder
Cairo University
2022-03-01 PHASE2; PHASE3
NCT02827747 WITHDRAWN
Keratoconus
University of Miami
2021-08-01 PHASE2
NCT05283954 WITHDRAWN
SARS-CoV2 Infection; COVID-19
Oriol Mitja
2022-05-01 PHASE2; PHASE3
NCT06102577 COMPLETED
Adverse Effects; Ascorbic Acid; Oxidative Stress
Centre Medicina Esportiva i Osteopatia, Spain
2021-11-01
NCT04344184 COMPLETED
COVID-19; Lung Injury, Acute; Kidney Injury
Virginia Commonwealth University
2020-12-18 PHASE2
NCT03918694 COMPLETED
Lumbar Spine Surgery
University of Kansas Medical Center
2019-06-30
NCT05129267 UNKNOWN
Periodontitis
Cairo University
2021-10-03
NCT03557229 UNKNOWN
Oxidative Stress; Septic Shock
American British Cowdray Medical Center
2018-07-23 PHASE3
NCT04335084 COMPLETED
COVID-19; Coronavirus Infection; Sars-CoV2; Corona Virus Infection; COVID; Coronavirus; Coronavirus-19; Coronavirus 19
ProgenaBiome
2020-06-22 PHASE2
NCT05527106 COMPLETED
Glaucoma
Institut Catala de Retina
2015-03-12
NCT04482686 COMPLETED
COVID; Covid-19; Corona Virus Infection; Coronavirus Infection; Coronavirus-19; SARS-CoV2; SARS-CoV Infection
ProgenaBiome
2020-12-09 PHASE1
NCT05360004 UNKNOWN
COVID-19
Hong Kong Baptist University
2022-05 PHASE2
NCT03829683 COMPLETED
Alcoholic Hepatitis; Sepsis
Virginia Commonwealth University
2019-04-16 PHASE2
NCT03964688 COMPLETED
Myeloma Multiple; Lymphoma
Maastricht University Medical Center
2019-12-10 PHASE2
NCT04682574 COMPLETED
Corona Virus Infection
University of Lahore
2020-11-02
NCT05127928 COMPLETED
Oxidative Stress
Universidad Europea de Madrid
2022-02-10
NCT05423873 COMPLETED
Hyperpigmentation; Photodamaged Skin; Wrinkle; Fine Lines
Revision Skincare
2021-03-17
NCT03725384 COMPLETED
Anemia; Iron Deficiency Anemia
Sunnybrook Health Sciences Centre
2019-01-04 PHASE3
NCT04955145 UNKNOWN
End Stage Renal Disease
Ain Shams University
2021-06-20 PHASE3
NCT04999137 UNKNOWN
Sepsis; Septic Shock; HIV
Liverpool School of Tropical Medicine
2021-09-01 PHASE2
NCT04708353 UNKNOWN
Gynecologic Disease
Zagazig University
2020-08-20
NCT03777514 WITHDRAWN
IDA in the Post-bariatric Surgical Patient
Johns Hopkins University
2019-08
NCT06236659 COMPLETED
Diet; Food; Nutrition
Rob Erskine
2019-12-01
NCT05009355 UNKNOWN
Vitamin C Deficiency
Cairo University
2019-01-11 EARLY_PHASE1
NCT03872011 COMPLETED
Septic Shock
Northern Jiangsu People's Hospital
2019-02-19 PHASE3
NCT03680274 COMPLETED
Sepsis; Vitamin C; Intensive Care Unit; COVID-19; Pandemic; Coronavirus
Université de Sherbrooke
2018-11-08 PHASE3
NCT04261036 WITHDRAWN
Catheter-Associated Urinary Tract Infection, Ascorbic Acid
American University of Beirut Medical Center
2019-07-20 EARLY_PHASE1
NCT03938584 COMPLETED
Vitamin C Deficiency; Smoking; Surgery; Surgery--Complications; Wound; Wound Complication; Wound Infection; Wound Dehiscence; Wound of Skin; Mandible Fracture; Mandible Open Fracture; Mandible Closed Fracture; Mandibular Fractures; Ascorbic Acid Deficiency; Oxidative Stress; Inflammation
Hennepin Healthcare Research Institute
2017-10-12
NCT01182792 UNKNOWN
Mountain Sickness; Chronic
University of Lausanne Hospitals
2008-10
NCT03592680 UNKNOWN
Atrial Fibrillation
Algemeen Ziekenhuis Maria Middelares
2018-10-01
NCT04828642 COMPLETED
Hypertrophy
Universidad Europea de Madrid
2021-02-01
NCT04279197 COMPLETED
Pulmonary Fibrosis Due to COVID-19
ShuGuang Hospital
2020-04-23 PHASE2
NCT03334409 TERMINATED
Clear Cell Renal Cell Carcinoma; Metastatic Clear Cell Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v7; Unresectable Renal Cell Carcinoma
Academic and Community Cancer Research United
2018-02-16 PHASE2
NCT03592277 COMPLETED
Sepsis; Septic Shock
Trinity Health Of New England
2018-09-14 PHASE2
NCT04347889 WITHDRAWN
Covid-19
Stony Brook University
2020-04-20 PHASE2
NCT04292886 UNKNOWN
Thin Endometrium
Nanjing University
2019-10-01
NCT04570254 COMPLETED
Pneumonia, Viral; Covid19; ARDS; Oxidative Stress
Unidad Temporal COVID-19 en Centro Citibanamex
2020-08-19
NCT04216459 COMPLETED
Major Trauma; Sepsis
Mansoura University
2020-02-18
NCT04508946 COMPLETED
Septic Shock; Sepsis; Organ Dysfunction Syndrome Sepsis
Air Force Specialized Hospital, Cairo, Egypt
2019-08-01 PHASE3
NCT04357782 COMPLETED
COVID-19; Hypoxia
Hunter Holmes Mcguire Veteran Affairs Medical Center
2020-04-16 PHASE1; PHASE2
NCT04370288 UNKNOWN
Covid-19
Mashhad University of Medical Sciences
2020-04-19 PHASE1
NCT04446104 COMPLETED
Covid-19
National University Hospital, Singapore
2020-05-13 PHASE3
NCT04197115 COMPLETED
Sepsis; Septic Shock
IMSS Hospital General de Zona 11, Piedras Negras
2019-09-01 PHASE3
NCT03338569 COMPLETED
Septic Shock; Sepsis
University of Minnesota
2017-12-20 PHASE2; PHASE3
NCT01125449 WITHDRAWN
Sarcoma; Adenocarcinoma; Carcinoma; Multiple Myeloma; Desmoplastic Small Round Cell Tumor
Situs Cancer Research Center
2020-01-01 PHASE2
NCT04036110 COMPLETED
Heart Failure
University of North Carolina, Chapel Hill
2018-08-14
NCT04886752 COMPLETED
Vitamin C Deficiency
TCI Co., Ltd.
2019-06-10
NCT03166787 TERMINATED
Smoking; Endothelial Dysfunction
Cedars-Sinai Medical Center
2017-08-15 PHASE1
NCT04697992 COMPLETED
Periorbital Hyperpigmentation
Kasr El Aini Hospital
2019-11-01
NCT03540628 COMPLETED
Septic Shock
Corewell Health South
2018-02-26
NCT03965637 COMPLETED
Abdominal Hysterectomy
Shahid Beheshti University
2019-08-23 PHASE3
NCT03756220 COMPLETED
Septic Shock; Sepsis
Tae Gun Shin
2018-12-01 PHASE2
NCT03821714 COMPLETED
Septic Shock
Southeast University, China
2019-02-01
NCT02639741 COMPLETED
Postoperative Pain
Cukurova University
2014-11 PHASE4
NCT01905150 COMPLETED
Pancreatic Cancer
Bruckner Oncology
2014-08-13 PHASE2
NCT03218280 UNKNOWN
Oxidative Stress; Polytrauma
Romanian Society of Anesthesia and Intensive Care
2017-01-01
NCT03707483 UNKNOWN
Periodontal Bone Loss
Cairo University
2019-02 PHASE2
NCT04215432 COMPLETED
Peri-implant Mucositis
Universidad Complutense de Madrid
2018-05-01
NCT03380507 TERMINATED
Septic Shock; Critical Illness
Hamad Medical Corporation
2018-03-17 PHASE2; PHASE3
NCT04283630 COMPLETED
Endothelial Dysfunction
David Travis Thomas
2018-02-05
NCT03509350 COMPLETED
Sepsis
Emory University
2018-08-22 PHASE3
NCT04137276 COMPLETED
Sepsis
Indonesia University
2019-04-01
NCT04469010 COMPLETED
Cognitive Function and Mood; Non-anaemic Iron Deficiency
Northumbria University
2017-06-02
NCT03333278 COMPLETED
Shock, Septic; Critically Ill; Vasoplegic Syndrome; Sepsis
Australian and New Zealand Intensive Care Research Centre
2018-05-02 PHASE2
NCT03800667 WITHDRAWN
Catheter-Associated Urinary Tract Infection, Ascorbic Acid
American University of Beirut Medical Center
2018-08-08 EARLY_PHASE1
NCT03451266 COMPLETED
Preeclampsia Severe; Preeclampsia Postpartum
University Medical Centre Ljubljana
2018-04-07 PHASE1
NCT04477018 COMPLETED
Iron; Cerebral Blood Flow; Energy Metabolism; Cognitive Function
Northumbria University
2017-11-11
NCT03123107 COMPLETED
Coronary Artery Bypass Graft Surgery
Geisinger Clinic
2017-07-06 PHASE1
NCT03610932 WITHDRAWN
Exercise-induced Bronchospasm
University of Kansas Medical Center
2018-07-01
NCT04093206 COMPLETED
Signs and Symptoms, Respiratory
Cargill
2017-12-22
NCT02791906 TERMINATED
Renal Insufficiency, Chronic
University of Pennsylvania
2016-05 PHASE2
NCT03258684 COMPLETED
Sepsis
Zhujiang Hospital
2017-09-25
NCT02631668 COMPLETED
Anemia, Iron-Deficiency
Huashan Hospital
2016-01-01 PHASE4
NCT03335124 TERMINATED
Sepsis; Septic Shock; Critical Illness; Fluid Overload
University Medical Centre Ljubljana
2017-09-26 PHASE4
NCT03224572 UNKNOWN
Vitamin C Deficiency
National Taiwan University Hospital
2018-01 PHASE1; PHASE2
NCT03029494 UNKNOWN
Temporomandibular Disorders
Croatian Science Foundation
2015-10-01
NCT03400020 COMPLETED
Postpolypectomy Bleeding
Ilam University of Medical Sciences
2018-01-28
NCT03719274 COMPLETED
Melanin Hyperpigmentation
Cairo University
2016-04
NCT03437902 COMPLETED
Type 2 Diabetes Mellitus
Ain Shams University
2018-02-24 PHASE2; PHASE3
NCT03148236 COMPLETED
Atrial Fibrillation Ablation
Virginia Commonwealth University
2017-09-18 PHASE2
NCT02762331 TERMINATED
Disorder of Vitamin C; Atrial Fibrillation; Complications Due to Coronary Artery Bypass Graft; Heart Valve Disease
Virginia Commonwealth University
2017-01-01 PHASE1
NCT03522922 COMPLETED
Acne Vulgaris; Acne Scars
Sohag University
2016-06-01 PHASE1; PHASE2
NCT04204200 COMPLETED
Complex Regional Pain Syndrome I of Lower Limb
Centre Hospitalier de Ham
2014-01-06
NCT03562988 COMPLETED
Dietary Exposure
Church & Dwight Company, Inc.
2017-08-01
NCT02216812 COMPLETED
Finger Stiffness; Distal Radius Fracture
Massachusetts General Hospital
2014-08
NCT03008655 UNKNOWN
Melasma
Taipei Medical University WanFang Hospital
2017-01
NCT03223519 COMPLETED
Delayed Onset Muscle Soreness, DOMS
Spherium Biomed
2017-07-12 PHASE2
NCT02106975 COMPLETED
Acute Lung Injury; Sepsis
Virginia Commonwealth University
2014-04 PHASE2
NCT02793648 COMPLETED
Depression
Yolanda de Diego Otero
2014-10 PHASE2
NCT01595516 COMPLETED
Prehypertension; Hypertension
University of Colorado, Boulder
2012-02 PHASE4
NCT02942498 COMPLETED
X Fragile Syndrome
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
2016-07 PHASE3
NCT02553551 UNKNOWN
Chronic Cholecystitis; Cholelithiasis
Taeho Hong
2015-07
NCT04078048 COMPLETED
Schizophrenia
University of Health Sciences Lahore
2017-04-27
NCT02971384 COMPLETED
Respiratory Tract Infection Viral
A. Vogel AG
2016-11-25 PHASE3
NCT02882451 UNKNOWN
Bile Duct Diseases
Changhai Hospital
2016-07
NCT01587261 WITHDRAWN
Severe Thermal Injury, Greater Than 20% TBSA
University of Texas Southwestern Medical Center
2017-06 PHASE2
NCT02877277 COMPLETED
Myelodysplastic Syndrome; Acute Myeloid Leukemia
Rigshospitalet, Denmark
2016-08-08
NCT02799134 COMPLETED
Healthy
qinshaozheng
2015-11
NCT02678234 WITHDRAWN
Infections, Respiratory Tract
GlaxoSmithKline
2017-02-01 PHASE3
NCT03221686 COMPLETED
Inguinal Hernia
Lars Nannestad Jorgensen
2016-02-20
NCT02898571 UNKNOWN
The Impact of Vitamin c and Epicatechin Upon Antioxidant Capactity
Newcastle University
2016-07
NCT02606981 COMPLETED
Diarrhea; Communicable Diseases
Stanford University
2015-07
NCT02758990 TERMINATED
Obesity; Rhinitis; Rhinitis, Allergic; Respiratory Sounds; Dyspnea; Headache; Migraine Disorders; Arthritis; Arthralgia; Anxiety; Sleep Initiation and Maintenance Disorders; Sleep Deprivation
Verifomics LLC
2016-03
NCT00862433 COMPLETED
Diabetes; Fatty Liver; Obesity; Healthy Volunteers
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
2014-10-10 PHASE1
NCT02455180 COMPLETED
Multiple Organ Failure; Sepsis; Systemic Inflammatory Response Syndrome; Trauma
Amsterdam UMC, location VUmc
2015-03 PHASE4
NCT00572741 COMPLETED
Autistic Disorder
Arkansas Children's Hospital Research Institute
2008-06
NCT02424201 UNKNOWN
Primary Postpartum Haemorrhage
Lagos State University
2015-06 EARLY_PHASE1
NCT02459756 COMPLETED
Vascular Stiffness; Inflammation
University of Reading
2015-06
NCT02606773 COMPLETED
Vitamin C Deficiency
Semmelweis University
2015-06 PHASE1
NCT02369822 UNKNOWN
Idiopathic Epilepsy
Ain Shams University
2015-02 PHASE2
NCT01426490 UNKNOWN
Colorectal Cancer
Taichung Veterans General Hospital
2011-08 PHASE2; PHASE3
NCT01210430 COMPLETED
Postural Tachycardia Syndrome
New York Medical College
2010-07 EARLY_PHASE1
NCT01329770 COMPLETED
Fragile X Syndrome
Yolanda de Diego Otero
2010-12 PHASE2
NCT01897792 TERMINATED
Coagulopathy; Nosocomial Pneumonia
University of Alabama at Birmingham
2013-05 PHASE2
NCT03260829 COMPLETED
Palatally Impacted Canines
Cairo University
2014-01
NCT02126644 UNKNOWN
Photoaging
National University Hospital, Singapore
2014-05 PHASE2
NCT03166956 COMPLETED
Critical Care
Chung Shan Medical University
2012-06-01
NCT02083575 UNKNOWN
Vitamin c; Thalassemia Major; Iron Chelation
Ain Shams University
2014-04 PHASE2; PHASE3
NCT01587963 TERMINATED
Shock
Rutgers, The State University of New Jersey
2013-02 PHASE2
NCT01413360 COMPLETED
Chronic Hepatitis; Chronic Hepatitis C; Chronic Alcoholic Hepatitis
Seoul National University Hospital
2011-08 PHASE4
NCT01537094 WITHDRAWN
Obese; Disorder of Vitamin C; Growth Hormone Secretion Abnormality
Massachusetts General Hospital
2013-12 PHASE2
NCT01338129 UNKNOWN
Ankle Fracture
Rabin Medical Center
2011-04
NCT01743742 COMPLETED
Birth Asphyxia
Sir Takhtasinhji General Hospital
2013-05 PHASE4
NCT00995670 COMPLETED
Hyperglycemia
US Department of Veterans Affairs
2010-03
NCT01590303 UNKNOWN
Severe Sepsis
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
2012-05 PHASE2
NCT01167569 COMPLETED
Reperfusion Injury
Rutgers, The State University of New Jersey
2007-10 PHASE4
NCT01434121 COMPLETED
Sepsis; Septic Shock; Hypotension; Acute Lung Injury
Virginia Commonwealth University
2010-05 PHASE1; PHASE2
NCT01032031 COMPLETED
Skin Cancer
University of Manchester
2009-03
NCT01321099 COMPLETED
Iron Deficiency; Anemia
Swiss Federal Institute of Technology
2011-05
NCT01356433 COMPLETED
Uremia; Inflammation
Peking University First Hospital
2011-08 PHASE4
NCT01283646 COMPLETED
Lack or Loss Appetite Nonorganic Origin
EMS
2011-10 PHASE3
NCT01558622 UNKNOWN
Laparoscopic Nissen Fundoplication
Kavaklıdere Umut Hospital
2012-03 PHASE4
NCT01162616 COMPLETED
Iron Absorption in Presence of Polyphenols
Swiss Federal Institute of Technology
2010-08 EARLY_PHASE1
NCT01944085 COMPLETED
Elbow Fracture
KK Women's and Children's Hospital
2008-10
NCT02248584 COMPLETED
Skin Neoplasms
University of Campinas, Brazil
2011-01
NCT00626444 TERMINATED
Non-Hodgkin Lymphoma
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
2008-02 PHASE2
NCT00954525 COMPLETED
Metastatic Pancreatic Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
2009-07 PHASE1
NCT01418898 UNKNOWN
Iron Deficiency Anemia
PepsiCo Global R&D
2011-08 PHASE4
NCT02132091 COMPLETED
Aging; Metabolism
University of Florida
2011-03
NCT00786019 COMPLETED
Type 2 Diabetes
University of Colorado, Denver
2008-05
NCT01630720 COMPLETED
Patients With Hypovitaminosis C and D; Vitamin Deficiencies
Jewish General Hospital
2011-06 PHASE2
NCT00893724 UNKNOWN
Neovascular Age-related Macular Degeneration; Diabetic Macular Edema
Mid-Atlantic Retina Consultations, Inc.
2009-06
NCT01322061 COMPLETED
Gallbladder Inflammation
American University of Beirut Medical Center
2010-11 PHASE4
NCT00270647 COMPLETED
Cancer; Prostate Cancer; Colorectal Cancer; Cardiovascular Disease; Eye Disease; Cognitive Decline
Brigham and Women's Hospital
1997-07
NCT00869427 TERMINATED
Urinary Tract Infection; Spinal Cord Injury
Sunnaas Rehabilitation Hospital
2009-03 PHASE4
NCT01188005 UNKNOWN
Obstructive Sleep Apnea Syndrome
University of Athens
2010-08
NCT01055418 COMPLETED
Endothelial Function; Cognition
Northumbria University
2010-01 PHASE4
NCT00985361 COMPLETED
Type 2 Diabetes Mellitus
ProMedica Health System
2009-10
NCT00704990 COMPLETED
Attention Deficit Hyperactivity Disorder
Kieran Cooley
2008-09 PHASE2; PHASE3
NCT00974025 COMPLETED
Fontan Procedure; Hypoplastic Left Heart Syndrome; Tricuspid Atresia
University of Michigan
2009-06
NCT00775541 TERMINATED
Type 2 Diabetes
In-Young Choi, Ph.D.
2007-10
NCT01125033 COMPLETED
Restless Legs Syndrome; Kidney Failure, Chronic
Shiraz University of Medical Sciences
2008-03 PHASE2; PHASE3
NCT00638560 COMPLETED
Obesity; Type 2 Diabetes
University of Leipzig
2008-03 PHASE1
NCT00135707 COMPLETED
Preeclampsia
The George Washington University Biostatistics Center
2003-06 PHASE3
NCT00625820 COMPLETED
Kidney Disease; Albuminuria
University of Michigan
2008-05 PHASE2
NCT00634998 COMPLETED
Diabetic Neuropathies
Washington State University
2007-11 PHASE1
NCT00633581 COMPLETED
Fatigue
DongGuk University
2008-03 PHASE2; PHASE3
NCT00570895 COMPLETED
Iron Deficiency
Baylor College of Medicine
2008-01
NCT00631111 COMPLETED
Pain
Wyeth is now a wholly owned subsidiary of Pfizer
2007-11 PHASE3
NCT00350077 WITHDRAWN
Burns
United States Army Institute of Surgical Research
2006-07
NCT00117403 COMPLETED
Alzheimer's Disease
National Institute on Aging (NIA)
2006-01 PHASE1
NCT00534014 COMPLETED
Atherosclerosis; Type 2 Diabetes
University of New Mexico
2006-01
NCT00284427 COMPLETED
Ovarian Cancer; Cervical Cancer; Uterine Cancer
Jeanne Drisko, MD, CNS, FACN
2005-09 PHASE2
NCT07206901 COMPLETED
Coronary Artery Disease
Maharishi International University
2002-10-14
NCT00624871 COMPLETED
Hypoxic Ischemic Encephalopathy; Perinatal Asphyxia
Al-Azhar University
2004-04
NCT00067899 COMPLETED
Smoking
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
2000-09 PHASE2
NCT00515736 TERMINATED
Critically Ill Patients; Cardiac Surgery; Trauma; Subarachnoid Hemorrhage
Centre Hospitalier Universitaire Vaudois
2003-01 PHASE3
NCT00712907 COMPLETED
Ocular Physiology; Regional Blood Flow
Medical University of Vienna
2003-02
NCT00001309 COMPLETED
Healthy Volunteers
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
1997-01-23 PHASE1
NCT00534924 UNKNOWN
Ischemia Reperfusion Injury
Medical University of Vienna
2007-08
NCT00000600 TERMINATED
Cardiovascular Diseases; Carotid Artery Diseases; Intracranial Arteriosclerosis; Cerebrovascular Disorders; Heart Diseases; Vascular Diseases; Atherosclerosis
National Heart, Lung, and Blood Institute (NHLBI)
1995-06 PHASE2
NCT00231218 COMPLETED
Common Cold; Gastroenteritis
The Cleveland Clinic
2006-01 PHASE3
NCT00001870 COMPLETED
Diabetes Mellitus, Non-Insulin Dependent; Non-Insulin Dependent
National Center for Complementary and Integrative Health (NCCIH)
1999-01 PHASE2
NCT00001070 WITHDRAWN
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00387114 TERMINATED
Metabolic Diseases; Oxidative Stress
University of Turin, Italy
2005-06 PHASE3
NCT00000161 UNKNOWN
Macular Degeneration; Cataract
National Eye Institute (NEI)
1993-08 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-06-26)

Check the L-Ascorbic Acid (Vitamin C) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

L-Ascorbic acid acts as an essential electron donor and antioxidant cofactor for key enzymatic reactions, directly scavenging reactive oxygen species and maintaining reduced intracellular redox states. By suppressing cellular oxidative stress and preserving vascular endothelial integrity, this mechanism directly contributes to its therapeutic efficacy in managing chronic pain, metabolic disorders such as type 2 diabetes, and systemic vitamin deficiencies.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.