CAS No. 79-81-2

Batch: Purity:99.11
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Retinyl (Vitamin A) Palmitate Chemical Structure
Chemical Structure
Check the Retinyl (Vitamin A) Palmitate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] hexadecanoate
CAS Number 79-81-2
Molecular Formula

C36H60O2
Molecular Weight (MW) 524.86
SMILES CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(CCCC1(C)C)C
InChIKey VYGQUTWHTHXGQB-FFHKNEKCSA-N

Biological Activity

Retinyl palmitate is a synthetic ester and storage precursor of vitamin A (retinol). Upon enzymatic hydrolysis to retinol and subsequent conversion into retinoic acid, it activates retinoic acid receptor (RAR) and retinoid X receptor (RXR) signaling pathways. This transcriptional regulation modulates essential gene expression downstream, governing cellular proliferation, epidermal differentiation, and tissue remodeling, while also demonstrating antioxidant activity that protects against cellular lipid peroxidation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 5 mg/mL
DMSO 3 mg/mL (5.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Duester G. Cell. 2008;134(6):921-31.

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Note: Technical data last updated: Sep 1, 2026.