Vismodegib (GDC-0449) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product Name: Vismodegib (GDC-0449)
Catalog Number: S1082
CAS Number: 879085-55-9
IUPAC Name: 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide

Relevant identified uses and uses advised against

Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

Company : Selleck Chemicals
TollFree : +1 877 796-6397
Tel : +1 832 582-8158
Fax : +1 832 582-8590

Emergency telephone number

Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

GHS Classification

Reproductive toxicity: Category 1B
Specific target organ toxicity - repeated exposure: Category 2
Short-term (acute) aquatic hazard: Category 1
Long-term (chronic) aquatic hazard: Category 1

GHS Label Elements
Pictogram: GHS08 , GHS09
Signal word: Danger

Hazard statements:

H360: May damage fertility or the unborn child.
H373: May cause damage to organs through prolonged or repeated exposure.
H410: Very toxic to aquatic life with long lasting effects.

Precautionary statements:

Prevention:
- P201: Obtain special instructions before use.
- P202: Do not handle until all safety precautions have been read and understood.
- P260: Do not breathe powder.
- P273: Avoid release to the environment.
- P280: Wear protective gloves/ protective clothing/ eye protection/ face protection.
Response:
- P308 + P313: IF exposed or concerned: Get medical advice/ attention.
- P391: Collect spillage.
Storage:
- P405: Store locked up.
Disposal:
- P501: Dispose of contents/ container to an approved waste disposal plant.

Other hazards:
None known.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Substance / Mixture: Substance
CAS-No.: 879085-55-9

Components:

Chemical name: 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide
CAS No.: 879085-55-9
Concentration (% w/w): >= 80 - <= 100 (The actual concentration is withheld as a trade secret)

4. FIRST AID MEASURES

General advice: Show this safety data sheet to the doctor in attendance.
If inhaled: After inhalation: fresh air. Call in physician.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact: After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed: After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Most important symptoms and effects, both acute and delayed: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11.
Protection of first-aiders: For personal protection see section 8.
Notes to physician: N/A.

5. FIREFIGHTING MEASURES

Suitable extinguishing media: Water, Foam, Carbon dioxide (CO2), Dry powder.
Unsuitable extinguishing media: For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting: Combustible. Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products: Carbon oxides, Nitrogen oxides (NOx), Sulphur oxides, Hydrogen chloride gas.
Specific extinguishing methods: N/A.
Further information: Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters: Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures:

Advice for non-emergency personnel: Avoid inhalation of powder. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
Advice for emergency responders: For personal protection see section 8.

Environmental precautions: Do not let product enter drains.
Methods and materials for containment and cleaning up: Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of powder.

7. HANDLING AND STORAGE

Advice on safe handling: Work under hood. Do not inhale substance/mixture. For precautions see section 2.
Further information on storage conditions: Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.
Storage class: 6.1C, Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects.
Recommended storage temperature: 36 - 86 °F / 2 - 30 °C.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Ingredients with workplace control parameters: Contains no substances with occupational exposure limit values.
Engineering measures: N/A.
Personal protective equipment:

Respiratory protection: Required when powder is generated. Recommended Filter type: Filter type P3.
Hand protection:
- Material: Nitrile rubber
- Break through time: 480 min
- Glove thickness: 0.11 mm
- Protective index: Full and Splash contact (KCL 741 Dermatril-L)
Eye protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses.
Skin and body protection: Protective clothing.
Hygiene measures: Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance: powder
Colour: N/A
Odour: N/A
Odour Threshold: N/A
pH: N/A
Melting point: N/A
Boiling point/boiling range: N/A
Flash point: Not applicable
Evaporation rate: N/A
Flammability (solid, gas): N/A
Flammability (liquids): N/A
Burning rate: N/A
Upper/Lower explosion limit: N/A
Vapour pressure: N/A
Relative vapour density: N/A
Relative density: N/A
Density: N/A
Water solubility: N/A
Partition coefficient: n-octanol/water: log Pow: 2.03 (77 °F / 25 °C) Method: (calculated). Bioaccumulation is not expected.
Autoignition temperature: N/A
Decomposition temperature: N/A
Viscosity, dynamic/kinematic: N/A
Explosive properties: Not classified as explosive.
Oxidizing properties: None
Molecular weight: 421.3 g/mol
Particle size: N/A

10. STABILITY AND REACTIVITY

Reactivity: The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a powder explosion potential may generally be assumed.
Chemical stability: The product is chemically stable under standard ambient conditions (room temperature).
Possibility of hazardous reactions: N/A.
Conditions to avoid: No information available.
Incompatible materials: Strong oxidizing agents.
Hazardous decomposition products: In the event of fire: see section 5.

11. TOXICOLOGICAL INFORMATION

Acute toxicity:

LD50 Oral - Rat - > 2,000 mg/kg (OECD Test Guideline 423)
Inhalation/Dermal: N/A

Skin corrosion/irritation: Skin - Rat; Result: No skin irritation (OECD Test Guideline 404).
Serious eye damage/eye irritation: N/A.
Respiratory or skin sensitization: N/A.
Germ cell mutagenicity: N/A.
Carcinogenicity:

IARC, NTP, OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen.

Reproductive toxicity: Suspected of damaging the unborn child. May damage the unborn child. May damage fertility. Developmental Toxicity - Rat - Oral.
Specific target organ toxicity - single exposure: N/A.
Specific target organ toxicity - repeated exposure: May cause damage to organs through prolonged or repeated exposure.
Aspiration hazard: N/A.
Additional Information: To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

12. ECOLOGICAL INFORMATION

Ecotoxicity (Components):

Toxicity to fish: LC50 (Brachydanio rerio): > 1.5 mg/l (96 h); NOEC: 1.5 mg/l (96 h).
Toxicity to daphnia and other aquatic invertebrates: EC50 (Daphnia magna): > 100 mg/l (48 h); NOEC: 0.85 mg/l (48 h). Chronic NOEC (Daphnia magna): 1.5 mg/l (21 d).
Toxicity to algae/aquatic plants: ErC50 (Desmodesmus subspicatus): 0.95 mg/l (72 h); ErC50 (Pseudokirchneriella subcapitata): 0.118 mg/l.
M-Factor (Acute/Chronic aquatic toxicity): 1 / 1.

Persistence and degradability: Biodegradation: 0% (28 d) (OECD Test Guideline 301F). Not readily biodegradable.
Bioaccumulative potential: log Pow: 2.03. Bioaccumulation is not expected.
Mobility in soil: N/A.
Other adverse effects: This product neither contains, nor was manufactured with a Class I or Class II ODS as defined by the U.S. Clean Air Act Section 602.
Endocrine disrupting properties: N/A.

13. DISPOSAL CONSIDERATIONS

Waste from residues: Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

14. TRANSPORT INFORMATION

IATA-DGR

UN/ID No.: UN 3077
Proper shipping name: Environmentally hazardous substance, powder, n.o.s. (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide)
Class: 9
Packing group: III
Labels: Class 9 - Miscellaneous dangerous substances and articles

IMDG-Code

UN number: UN 3077
Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, POWDER, N.O.S. (2-chloro-N-(4-chloro-

16. OTHER INFORMATION

Revision Date: 2026/07/20
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.