Vismodegib (GDC-0449) is a potent, small-molecule Smoothened (SMO) antagonist. It affects the Hedgehog (Hh) signaling pathway by binding to the SMO receptor and blocking downstream GLI activation, thereby inhibiting cancer cell proliferation, invasion, and inducing apoptosis.
Vismodegib (GDC-0449) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Vismodegib (GDC-0449) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.