CAS No. 143-67-9

Batch: Purity:99.91
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Vinblastine sulfate Chemical Structure
Chemical Structure
Check the Vinblastine sulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 143-67-9
Molecular Formula

C46H58N4O9.H2SO4
Molecular Weight (MW) 909.05
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

Ordering Information

Biological Activity

Vinblastine sulfate is a microtubule-disrupting agent that inhibits microtubule assembly and suppresses nicotinic acetylcholine receptor (nAChR) activity. Disruption of microtubule dynamics leads to mitotic arrest at the metaphase-anaphase transition and downstream inhibition of cellular proliferation. Additionally, treatment with vinblastine sulfate promotes intracellular autophagy and triggers apoptotic pathways in susceptible cancer cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (110.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 50 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.