CAS No. 152-11-4
Batch:
Purity:99.99
Chemical Structure
Check the
Verapamil HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 152-11-4 | |
|---|---|---|
| Molecular Formula |
C27H38N2O4.HCl |
|
| Molecular Weight (MW) | 491.06 | |
| SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl |
Verapamil HCl is an L-type calcium channel blocker and class IV anti-arrhythmic agent. It inhibits transmembrane calcium influx into cardiac and vascular smooth muscle cells, leading to reduced myocardial contractility and arterial vasodilation. Additionally, Verapamil inhibits permeability-glycoprotein (P-gp)-mediated transport to suppress multidrug resistance and acts as an inhibitor of cytochrome P450 3A4 (CYP3A4). [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
| Ethanol | 12 mg/mL |
| DMSO |
98 mg/mL
(199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 98 mg/mL |
| Ethanol | 98 mg/mL |
| DMSO |
98 mg/mL
(199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 98 mg/mL |
| Ethanol | 98 mg/mL |
| DMSO |
98 mg/mL
(199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
| Ethanol | 12 mg/mL |
| DMSO |
98 mg/mL
(199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 98 mg/mL |
| Ethanol | 49 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.