ABT-199 (Venetoclax): Selectivity & Specificity
ABT-199 (Venetoclax) is a potent inhibitor of BCL-2 (IC50 = 1.2 nM), BCL-XL (IC50 = 49 nM), ADAM17 (IC50 = 480 nM), BFL-1 (IC50 > 3000 nM), MCL-1 (IC50 > 30000 nM), and Hepsin. ABT-199 (Venetoclax) exhibits the greatest inhibitory potency toward BCL-2 (IC50 = 1.2 nM).