CAS No. 2089227-65-4
| IUPAC Name | 2-[[4-anilino-1-(naphthalen-1-ylmethyl)piperidine-4-carbonyl]amino]acetic acid | |
|---|---|---|
| CAS Number | 2089227-65-4 | |
| Molecular Formula |
C25H27N3O3 |
|
| Molecular Weight (MW) | 417.50 | |
| SMILES | C1CN(CCC1(C(=O)NCC(=O)O)NC2=CC=CC=C2)CC3=CC=CC4=CC=CC=C43 | |
| InChIKey | JZDHWOWCHGYSGA-UHFFFAOYSA-N |
VBIT-12 is a synthetic small-molecule inhibitor of voltage-dependent anion-selective channel 1 (VDAC1). By directly interacting with purified VDAC1, VBIT-12 effectively reduces channel conductance and blocks apoptosis-associated VDAC1 oligomerization. Inhibiting this oligomerization prevents mitochondrial outer membrane permeabilization and subsequent release of pro-apoptotic factors such as cytochrome c, thereby attenuating mitochondrial-mediated cell death pathways across various cell lines and preclinical disease models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(198.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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