CAS No. 99-66-1
Batch:
Purity:99.04
Chemical Structure
Check the
VPA (Valproic acid)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-propylpentanoic acid | |
|---|---|---|
| CAS Number | 99-66-1 | |
| Molecular Formula |
C8H16O2 |
|
| Molecular Weight (MW) | 144.21 | |
| SMILES | CCCC(CCC)C(=O)O | |
| InChIKey | NIJJYAXOARWZEE-UHFFFAOYSA-N |
VPA (Valproic acid) is a short-chain fatty acid that acts as a histone deacetylase (HDAC) inhibitor. It modulates cellular signaling pathways by activating Notch-1 signaling and upregulating expression of BNIP3 and PGC-1α. Through these mechanisms, valproic acid induces autophagy, mitophagy, and mitochondrial biogenesis, while regulating gene expression and cellular differentiation in various cell models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
29 mg/mL
(201.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 29 mg/mL |
| Ethanol | 29 mg/mL |
| DMSO |
29 mg/mL
(201.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 29 mg/mL |
| Water | 2 mg/mL |
| DMSO |
100 mg/mL
(693.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | 2 mg/mL (超声加热五分钟) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- VPA (Valproic acid) Mechanism of Action: HDAC Inhibition in Tumor Cell Research
- VPA (Valproic acid) Clinical Trials
- VPA (Valproic acid) Solubility in DMSO
- VPA (Valproic acid) Stock Solution
- VPA (Valproic acid) Storage
- VPA (Valproic acid) Stability
- VPA (Valproic acid) Molecular Weight
- VPA (Valproic acid) SMILES
- VPA (Valproic acid) Chemical Structure (2D and 3D)
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- VPA (Valproic acid) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.