CAS No. 124832-27-5

Batch: Purity: 99.447
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Valaciclovir HCl Chemical Structure
Chemical Structure
Check the Valaciclovir HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate;hydrochloride
CAS Number 124832-27-5
Molecular Formula

C13H20N6O4.HCl
Molecular Weight (MW) 360.8
SMILES CC(C)C(C(=O)OCCOCN1C=NC2=C1N=C(NC2=O)N)N.Cl
InChIKey ZCDDBUOENGJMLV-QRPNPIFTSA-N

Ordering Information

Biological Activity

Valaciclovir HCl is an L-valyl ester prodrug of acyclovir that acts as an antiviral agent. Upon enzymatic conversion to acyclovir, it undergoes sequential intracellular phosphorylation to acyclovir triphosphate, which selectively inhibits viral DNA polymerase. This competitive inhibition prevents viral DNA synthesis, leading to chain termination and suppression of viral replication in herpes simplex virus and varicella-zoster virus. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (199.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 72 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.