Vactosertib (TEW-7197): Selectivity & Specificity
Vactosertib (TEW-7197) is a potent inhibitor of TGF-β RI/ALK-5 (12.9 nM), ALK-2 (17.3 nM), ALK-4 (17.3 nM). Vactosertib (TEW-7197) exhibits the greatest inhibitory potency toward TGF-β RI/ALK-5 (IC50 = 12.9 nM).