CAS No. 1352608-82-2
Batch:
Purity:99.57
Chemical Structure
Check the
Vactosertib (TEW-7197)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-fluoro-N-[[5-(6-methyl-2-pyridinyl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methyl]aniline | |
|---|---|---|
| CAS Number | 1352608-82-2 | |
| Molecular Formula |
C22H18FN7 |
|
| Molecular Weight (MW) | 399.42 | |
| SMILES | CC1=NC(=CC=C1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4 | |
| InChIKey | FJCDSQATIJKQKA-UHFFFAOYSA-N |
Vactosertib (TEW-7197) is a potent, selective, and orally bioavailable TGF-β receptor inhibitor targeting ALK4 (IC50 = and ALK5 (IC50 =. By inhibiting ALK4 and ALK5, Vactosertib blocks downstream TGF-β/Smad signaling pathways, suppressing Smad2 and Smad3 phosphorylation. This mechanism effectively attenuates epithelial-to-mesenchymal transition (EMT), tumor cell migration, invasion, and tissue fibrosis in preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(197.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 79 mg/mL |
| Water | Insoluble |
| DMSO |
80 mg/mL
(200.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 80 mg/mL |
| Water | Insoluble |
| DMSO |
79 mg/mL
(197.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 79 mg/mL |
| Water | Insoluble |
| DMSO |
80 mg/mL
(200.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 27 mg/mL |
| Water | Insoluble |
| DMSO |
80 mg/mL
(200.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 80 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Vactosertib (TEW-7197) Mechanism of Action: TGFBR1 Inhibition in T Cell Research
- Vactosertib (TEW-7197) Clinical Trials
- Vactosertib (TEW-7197): Selectivity & Specificity
- Vactosertib (TEW-7197) Working Concentration | Cell Culture | Treatment
- Vactosertib (TEW-7197) Solubility in DMSO
- Vactosertib (TEW-7197) Stock Solution
- Vactosertib (TEW-7197) Storage
- Vactosertib (TEW-7197) Stability
- Vactosertib (TEW-7197) Combination Database
- Vactosertib (TEW-7197) Molecular Weight
- Vactosertib (TEW-7197) SMILES
- Vactosertib (TEW-7197) Chemical Structure (2D and 3D)
- Vactosertib (TEW-7197) IC50 for Cell-based and Cell-free Assays
- Vactosertib (TEW-7197) MedChemExpress (HY-19928)? Try a better option.
- Vactosertib (TEW-7197) Cayman (19231)? Try a better option.
- Vactosertib (TEW-7197) Abmole (M5246)? Try a better option.
- Vactosertib (TEW-7197) Sigma (AMBH2D6FB2FA)? Try a better option.
- Vactosertib (TEW-7197) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.