CAS No. 2851040-81-6
Batch:
Purity:99.46
Chemical Structure
Check the
USP5-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[[5-[4-(4-chlorophenyl)piperidin-1-yl]sulfonylpyridine-2-carbonyl]amino]acetic acid | |
|---|---|---|
| CAS Number | 2851040-81-6 | |
| Molecular Formula |
C19H20ClN3O5S |
|
| Molecular Weight (MW) | 437.90 | |
| SMILES | O=S(C1=CC=C(C(NCC(O)=O)=O)N=C1)(N2CCC(C3=CC=C(Cl)C=C3)CC2)=O | |
| InChIKey | HIWYRXWPCQHOSO-UHFFFAOYSA-N |
USP5-IN-1 is a selective, competitive inhibitor of the USP5 zinc finger ubiquitin-binding domain (ZnF-UBD) with a KD of 2.8 μM. By targeting the ZnF-UBD site, it suppresses USP5 catalytic activity and inhibits the hydrolysis of unanchored ubiquitin chains. This disruption impairs ubiquitin homeostasis and modulates downstream ubiquitin-dependent signaling pathways and cellular protein degradation.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
| DMSO |
88 mg/mL
(200.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.