Urea SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Urea
CAS Number: 57-13-6
PubChem CID: 1176
Molecular formula: CH4N2O
Molecular weight: 60.056 g/mol
IUPAC name: urea

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Fresh air, rest.
Skin contact: Rinse and then wash skin with water and soap.
Eye contact: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion: Give one or two glasses of water to drink. Rest.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
Fire Extinguishing Agents: Water (USCG, 1999)
In case of fire in the surroundings, use appropriate extinguishing media.

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
Water Spill: Contain by damming, water diversion or natural barriers. Remove and treat contaminated liquids. Absorb small amounts of liquid spill with natural or synthetic sorbents, shovel into containers and cover.
If urea is spilled in solid form, shovel material into containers and cover. Construct barriers to contain solutions or divert to impermeable holding area. Remove material by manual or mechanical means.
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Urea is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. Incinerator is equipped with a scrubber or thermal unit to reduce nitrogen oxide emissions.
The following wastewater treatment technology has been investigated for urea: Concentration process: Biological treatment.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

7.1 Precautions for safe handling
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. (NTP, 1992)
Separated from incompatible materials. See Chemical Dangers.

7.2 Conditions for safe storage, including any incompatibilities
Separated from incompatible materials. See Chemical Dangers.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]

9.1 Information on basic physical and chemical properties
a) Appearance: Urea appears as solid odorless white crystals or pellets. Density 1.335 g /cc. Noncombustible.
b) Odor: MAY GRADUALLY DEVELOP SLIGHT ODOR OF AMMONIA, ESP IN PRESENCE OF MOISTURE
c) Odor threshold: No data available
d) pH: 7.2 (10% solution)
e) Melting point/freezing point: 275 °F (NTP, 1992)
f) Initial boiling point and boiling range: Decomposes (NTP, 1992)
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 0.000012 [mmHg]
l) Vapor density: No data available
m) Relative density: 1.34 at 68 °F (USCG, 1999) - Denser than water; will sink
n) Water solubility: Soluble (NTP, 1992)
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): -1.4
p) Auto-ignition temperature: Not flammable (USCG, 1999)
q) Decomposition temperature: No data available
r) Viscosity: 1.78 mPa-s (46% solution @ 20 °C); 1.81 mP-s @ 137 °C; 1.90 mPa-s (saturated solution @ 20 °C)
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 69.1 Ų
Complexity: 29

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
No data available.
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
No data available.
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Exposure routes:
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Signs and symptoms of exposure:
Cough. Shortness of breath. Sore throat.
Redness.
Redness.
Convulsions. Headache. Nausea. Vomiting.
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
Toxicity threshold: Scenedesmus quadricauda (green algae) >10,000 mg/l, toxic effect: multiplication inhibition of cell. /Time not specified/
Toxicity threshold: Entosiphon sulcatum (protozoa) >29 mg/l, toxic effect: inhibition of cell multiplication. /Time not specified/
Toxicity threshold: Pseudomonas putida >10,000 mg/l; toxic effect: inhibition of cell multiplication. /Time not specified/
Urea's production and use as a fertilizer and animal feed is expected to result in its direct release to the environment. Urea's production and use as a chemical intermediate, stabilizer in explosives, medicine, and viscosity modifier, and in plastics, adhesives, pharmaceuticals, cosmetics, dentifrices, flameproofing agents, and preparation of biuret may result in its release to the environment through various waste streams. Urea is a natural product of nitrogen and protein metabolism; and it is found in urine and animal waste. If released to air, a vapor pressure of 1.20X10-5 mm Hg at 25 °C indicates urea will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase urea will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 9.6 hrs. Particulate-phase urea will be removed from the atmosphere by wet and dry deposition. If released to soil, urea is expected to have very high mobility based upon a Koc of 8. Volatilization from moist soil surfaces is not expected t

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): -1.4
Low potential for bioaccumulation (Log P < 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
No other adverse ecological effects identified.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: No (not classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
No SARA Hazards.

Massachusetts Right To Know Components:
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components:
No components are subject to the Pennsylvania Right to Know Act.
New Jersey Right To Know Components:
No components are subject to the New Jersey Right to Know Act.

California Prop. 65 Components:
This product contains a chemical known to the State of California to cause cancer, birth defects, or other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: Urea
- EFSA Legal Basis: Commission Regulation (EC) No 2229/2004
- Status Regulation (EC): Reg. (EU) 2022/708, 2008/127, Reg. (EU) 2017/195, Reg. (EU) 2018/155, Reg. (EU) 2020/1160, Reg. (EU) 2021/745, Reg. (EU) 2023/1446, Reg. (EU) 2024/839, Reg. (EU) No 540/2011, Reg. (EU) No 597/2012
- Atmospheric Standards: This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to us
- FIFRA Requirements: As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.