CAS No. 1048371-03-4
Batch:
Purity:99.87
Chemical Structure
Check the
UPF 1069
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-phenacyloxy-2H-isoquinolin-1-one | |
|---|---|---|
| CAS Number | 1048371-03-4 | |
| Molecular Formula |
C17H13NO3 |
|
| Molecular Weight (MW) | 279.29 | |
| SMILES | C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O | |
| InChIKey | JJWMRRNGWSITSQ-UHFFFAOYSA-N |
UPF 1069 is a selective small-molecule inhibitor of poly(ADP-ribose) polymerase 2 (PARP2). By suppressing PARP enzymatic activity, it impairs cellular DNA repair pathways and leads to the accumulation of DNA strand breaks. This disruption promotes genomic instability and triggers apoptotic cell death, thereby attenuating tumor cell proliferation and survival in DNA damage-sensitive models. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(200.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
56 mg/mL
(200.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.