ABT-494 (Upadacitinib): Selectivity & Specificity
ABT-494 (Upadacitinib) is a potent inhibitor of JAK1 (0.76/40/43 nM), JAK2 (19/120 nM), JAK3 (224/2300 nM), TYK2 (118/4700 nM). ABT-494 (Upadacitinib) exhibits the greatest inhibitory potency toward JAK1 (IC50 = 0.76 nM).