CAS No. 473921-12-9

Batch: Purity:99.50
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Lersivirine (UK-453061) Chemical Structure
Chemical Structure
Check the Lersivirine (UK-453061) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[3,5-diethyl-1-(2-hydroxyethyl)pyrazol-4-yl]oxybenzene-1,3-dicarbonitrile
CAS Number 473921-12-9
Molecular Formula

C17H18N4O2
Molecular Weight (MW) 310.35
SMILES CCC1=C(C(=NN1CCO)CC)OC2=CC(=CC(=C2)C#N)C#N
InChIKey MCPUZZJBAHRIPO-UHFFFAOYSA-N

Biological Activity

Lersivirine (UK-453061) is a potent and selective non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV-1 reverse transcriptase. By binding to a non-catalytic allosteric pocket on reverse transcriptase, it inhibits viral RNA-dependent DNA polymerase activity and blocks viral DNA synthesis. This inhibition suppresses viral replication in infected host cells and impairs retroviral lifecycle progression. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 62 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Corbau R, et al. Antimicrob Agents Chemother. 2010;54(10):4451-63.

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Note: Technical data last updated: Sep 1, 2026.