CAS No. 256476-36-5

Batch: Purity:99.56
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UK-371804 HCl Chemical Structure
Chemical Structure
Check the UK-371804 HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[4-chloro-1-(diaminomethylideneamino)isoquinolin-7-yl]sulfonylamino]-2-methylpropanoic acid;hydrochloride
CAS Number 256476-36-5
Molecular Formula

C14H16ClN5O4S.HCl
Molecular Weight (MW) 422.29
SMILES CC(C)(C(=O)O)NS(=O)(=O)C1=CC2=C(C=C1)C(=CN=C2N=C(N)N)Cl.Cl
InChIKey IUBFETAFRGVODB-UHFFFAOYSA-N

Ordering Information

Biological Activity

UK-371804 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM. It exhibits high selectivity for uPA, showing 4000-fold selectivity over tissue-type plasminogen activator (tPA) and 2700-fold over plasmin. By inhibiting uPA, UK-371804 suppresses plasminogen activation to plasmin, thereby downregulating extracellular matrix degradation and pericellular proteolysis pathways.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 42 mg/mL (99.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.