CAS No. 537672-41-6

Batch: Purity:99.58
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UF010 Chemical Structure
Chemical Structure
Check the UF010 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-bromo-N'-butylbenzohydrazide
CAS Number 537672-41-6
Molecular Formula

C11H15BrN2O
Molecular Weight (MW) 271.15
SMILES CCCCNNC(=O)C1=CC=C(C=C1)Br
InChIKey BVQCFCYPFJOOAV-UHFFFAOYSA-N

Biological Activity

UF010 is a class I-selective histone deacetylase (HDAC) inhibitor that potently targets HDAC1, HDAC2, HDAC3, and HDAC8, with additional activity against HDAC6 and HDAC10. By inhibiting class I HDACs, it promotes hyperacetylation of histones, inducing chromatin remodeling and transcriptional modulation. These downstream effects disrupt cell cycle progression and inhibit cell proliferation, suppressing cancer cell growth. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 54 mg/mL (199.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 54 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Falkenberg KJ, et al. Nat Rev Drug Discov. 2014;13(9):673-91.

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Note: Technical data last updated: Sep 1, 2026.